急性淋巴细胞白血病患儿内源性一氧化碳动态检测意义  

Changs of endogenous carbon monoxide in child of acute lymphoblastic leukemia

作　　者：王菊香[1] 朱新波[2] 李原[1] 阮积晨[1] 钱江潮[1] 周海霞[1] 曾炜炜[1] 黄珍[1] 方希敏[1] 

机构地区：[1]温州医学院附属育英儿童医院血液科,浙江325027 [2]温州医学院药理学教研室,浙江325035

出　　处：《中国小儿血液与肿瘤杂志》2009年第1期23-25,共3页Journal of China Pediatric Blood and Cancer

基　　金：浙江省医药卫生科学研究基金资助项目(20058124)

摘　　要：目的了解单独化疗对急性淋巴细胞白血病(ALL)患儿一氧化碳(CO)动态变化。方法应用Chalmers血红蛋白结合法及联二亚硫酸盐还原法检测了24例正常儿童,22例ALL患儿在化疗前、化疗中、缓解后以及长期缓解期血浆一氧化碳水平。结果ALL患儿化疗前血浆一氧化碳浓度为(1.98±0.26)mg/L,较正常儿童的(1.09±0.15)mg/L为高,差异有显著性意义(P>0.01),化疗中一氧化碳浓度(2.01±0.18)mg/L,缓解后(1.96±0.22)mg/L,差异无显著性意义(P>0.05),但长期缓解患儿血浆一氧化碳浓度为(1.10±0.16)mg/L,差异有显著性意义(P<0.01)。结论白血病化疗可使体内产生过量的一氧化碳,但随着时间的延长,这种影响会逐渐消失。Objective To observe changes of carbon monoxide in childen of acute lymphoblastic leukemia with chemical treatment. Methods We examined CO levels in plasma of 22 childen of acute lymphoblastic leukemia and 24 matched normal childen. Results Childen of acute lymphoblastic leukemia before chemical treatment stage had increased levels of CO in plasma compared with normal control subjects （ P 〈 0. 01 ）, while in chemical treatment stage and in complete relief stage had same levels of CO in plasma compared with before chemical treatment stage （ P 〉 0. 05 ） , but in long-term complete relief stage plasma CO reduced to normal levels （P 〈 0. 01 ）. Conclusion Our present data showed that endogenously produced CO was increased during the course of leukemia. However, with the development of time, the levels of CO in plasma reduced to normal levels.

关 键 词：一氧化碳 急性淋巴细胞白血病 儿童 

分 类 号：R733.71[医药卫生—肿瘤] R338[医药卫生—临床医学]