气温、气压、湿度的变化对消化性溃疡发病影响的研究  

Study of Relationship Between the Onset of Peptic Ulcer and Temperature,Air Pressure and Humidity

作　　者：刘达云[1] 高安宁[2] 唐国都[3] 黄钢丁[1] 孙丽玲[1] 覃江[4] 谢月萍[1] 杨望月[2] 梁仲惠[5] 苏东星[6] 

机构地区：[1]广西南宁市第一人民医院,南宁530022 [2]广西气象台 [3]广西医科大学第一附属医院 [4]广西壮族自治区人民医院 [5]中国人民解放军303医院 [6]广西南宁市第二人民医院

出　　处：《临床消化病杂志》2009年第1期3-7,共5页Chinese Journal of Clinical Gastroenterology

基　　金：广西科学研究与技术开发计划项目基金资助(No.9920025)

摘　　要：目的研究候气温、气压、湿度等气象因子变化对消化性溃疡发病的影响及探讨其导致消化性溃疡的发病机理。方法用2003年和2004年南宁市逐候(5 d)的平均气温、平均最高气温、平均最低气温,平均气压和平均露点温度,代入已经研究建立的南宁市候的消化性溃疡内镜检出率(DRPU)预测模型(Y侯DRPU):Y候DRPU=-9.826-0.13995Tpj-0.00568Tmax-0.24365Tmin+0.04104P+0.00342Td进行前瞻性预测南宁市候的DRPU,所得结果与南宁市实测的DRPU对照分析,按预测模型允许的平均误差率4.06%评定为准确。结果(1)2003年72个候的预测结果中与实侧值比较,基本相符为55/72候,相符率达76.39%。(2)2004年在72个侯的预测结果中与实测值比较,基本相符为52/72候,相符率达72.22%。上述2年144个侯的预测结果与实测值比较,基本相符为107/144候,相符率平均达74.31%。结论候的平均气温值、平均最高气温值、平均最低气温值、平均气压及平均露点温度等气象因子变化与消化性溃疡发病密切相关。依据前期侯的这些气象因子的变化,预测DRPU的方程对PU候发病的趋势上有较高的准确性和可靠性。寒冷气温和气压湿度剧变等急性、亚急性应激变化可导致机体肾上腺素、去甲肾上腺素、血管紧张素Ⅱ、内皮素的分泌显著增高,生长抑素分泌减少,胃泌素水平升高,5-HT增加,血浆前列腺素E2和一氧化氮水平降低,表皮生长因子水平下降,免疫功能下降,引起黏膜缺血缺氧损伤,胃酸分泌增高,幽门螺杆菌感染增加。上述多方面的综合作用,可能正是消化性溃疡冬春季发病明显增高的原因。Objective Investigate the relationship between the onset of peptic ulcer（PU） and temperature, air pressure, humidity and the pathogenesis of PU. Methods We put the average temperature, average maximum temperature, average minimum temperature, average air pressure, average dew point temperature every five days on the city of Nanning from 2003 to 2004 into the forecasting model （YDRPU） of detectable rate of PU （DRPU） conclusion, which was YDRPU = - 9. 826 - 0. 13995Tpj - 0. 00568Tmax- 0. 24365Tmin ＋ 0. 04104P ＋ 0. 00342Td to forecast DRPU on every five day in Nanning. To compare the result and the actual DRPU, YDRPU permitted average error rate 4. 06% was accurate. Results （ 1 ） To compare the forecasting result and the actual DRPU on 72 every five day in 2003, we found 55/72 every five day was approximately coincident. Accordance rate was 76. 39%. （2） Comparing the forecasting result and the actual DRPU on 72 every five day in 2000 ,we found 52/72 every five day was approximately coincident. Accordance rate was 72.22%. Comparing the forecasiting result and the actual DR19U on 72 every five day in the two years,we found 107/144 every five day was approximately coincident. Accordance rate was 74. 31% . Conclusion There was a close relationship between onset of peptic ulcer and average temperature, average maximum temperature, average minimum temperature, average air pressure, average dew point temperature. According to the change of the meteorological factors （MF）, the forecasting model had veracity and dependability on forecasting the onset of peptic ulcer every five day. When the temperature, air pressure and humidity changed rapidly, the secretions of epinephrine, norepinephrine, angiotensin Ⅱ, endothelin increased, the secretions of somatostain decreased, gastrin and 5-HT increased, prostaglandin-E2 , carbon monoxide, skin factor, immune factor decreased, which could induce ischemic, anoxic, injuered in gastric mucosa and the secretion of hydrochloric acid and helicobacter pylori in

关 键 词：消化性溃疡 气温 气压 湿度 

分 类 号：R573.1[医药卫生—消化系统]