非酒精性脂肪肝患者血清抵抗素与胰岛素抵抗关系的研究  

Relationship Between the Serum Resistin and Insulin Resistance in Nonalcoholic Fatty Liver Disease

作　　者：汪明涛[1] 陈范嵘[1] 朱春燕[1] 戚红霞[1] 朱健焕[1] 

机构地区：[1]上海市普陀区人民医院消化科,上海200060

出　　处：《临床消化病杂志》2009年第1期31-33,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨非酒精性脂肪肝患者血清抵抗素水平及其与肥胖、胰岛素抵抗、血糖、血脂的关系。方法选择非酒精性脂肪肝患者100例,正常对照30例,采用ELISA方法测定空腹血清抵抗素,同时检测其身高、体重、腰围、臀围、血糖、血脂、肝功能及胰岛素水平,并计算体重指数、腰臀比和胰岛素敏感指数。结果非酒精性脂肪肝患者血清抵抗素水平为17.68±5.2 ng/ml,高于正常对照组的12.85±4.4 ng/ml,P<0.01。相关分析显示,血清抵抗素与体重指数、甘油三酯呈正相关关系(分别为r=0.376、0.426,P<0.05),与胰岛素敏感指数呈负相关关系,(r=-0.584,P<0.01),而与腰臀比、总胆固醇、低密度酯蛋白胆固醇、高密度脂蛋白胆固醇、血糖无相关性,(P>0.05)。结论在非酒精性脂肪肝的发病过程中,抵抗素可能参与了胰岛素抵抗。Objective To investigate the level of serum resistin in patients with nonalcoholic fatty liver disease（NAFLD） and its relationship with obesity, insulin sensitivity, blood glucose, and blood lipid. Methods 100 patients with nonalcoholic fatty liver disease（ NAFLD group） and 30 normal subjects（ control group） were selected. The level of serum resistin was measured by ELISA method, Height, weight, waist circumstance, hip girth, fasting blood glucose （ FBG）, blood lipid （ TC, TG, HDL-C, LDL-C）, liver function （ AST, ALT）, and fasting insulin （FIN） were measured. Body mass index （BMI） , waist to hip ratio （WHR） were calculated as well. Insulin sensitivity was analyzed using insulin sensitive index（ISI）. Results Serum resistin levels were higher in NAFLD patients as compared to controls. （ 17. 68 ± 5. 2 ng/ml vs 12. 85± 4. 41 ng/ml, P 〈 0.01 ）. There was no significant correlation between serum resistin （depend variable） and WHR, TCH, LDL, HDL, FBG. Serum resistin were positively correlated with BMI,TG（ r =0. 376,0.426, P 〈0.05） ,but negatively correlated with ISI（ r = -0. 584, P 〈0.01）. Conclusion Serum resistin is involved in the insulin resistance during the development of nonalcoholic fatty liver disease.

关 键 词：非酒精性脂肪肝 抵抗素 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]