脆性组氨酸三联体基因在宫颈癌组织中的表达及临床意义  

Expression of FHIT gene in cervical carcinoma

作　　者：韩丽丽[1] 李艳兵[2] 王惠君[1] 

机构地区：[1]滨州市人民医院妇科,山东省滨州256610 [2]山东省济南市第三人民医院产科

出　　处：《中国基层医药》2009年第1期65-67,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨宫颈癌组织中脆性组氨酸三联体（FHIT）基因的表达及其与临床病理指标的关系。方法应用免疫组织化学SP法检测FHIT在42例宫颈癌组织及13例癌旁组织中的表达。结果宫颈癌组织中FHIT蛋白阳性表达率显著低于癌旁组织（47．6％与92．3％，P〈0．01）。宫颈癌高、中分化组FHIT蛋白阳性表达率显著高于低分化组（54．2％与38．9％，P〈0．01）；淋巴结转移患者FHIT蛋白阳性表达率显著低于无淋巴转移组（45．9％与60．0％，P〈0．05）；临床病理Ⅰ期组FHIT蛋白阳性表达率显著高于Ⅱ期组（55．0％与45．5％，P〈0．05）。结论FHIT基因在宫颈癌的发生、发展中起重要作用，对其蛋白的检测可作为判断宫颈癌发生及转移能力的一项客观指标。Objective To investigate the expression of fragile histidine triad（ FHIT） gene in cervical carcinoma and relationship with its clinical-pathological implication. Methods The expression of FHIT was detected by immunohistochemistry SP method in 42 cases of cervical carcinoma and 13 cases of adjacent tissue. Results 47.6% {20 of 42） of cases expressed FHIT in the tumor cells,and 92.3% （ 12 of 13） of cases of the adjacent tissue were present. There was a significant positive correlation between cervical carcinoma and adjacent tissue（P 〈0. 01 ）. The positive rates of FHIT in high and middle degrees of differentiation were significantly higher than that in low degree of differentiation（54. 2% vs 38. 9% ）. Tumors with lymph node metastases（45. 9% ） had loss FHIT protein expression than those without metastasis（60. 0% ） （P 〈0. 05）. The FHIT expression betweenⅠ and Ⅱ stage,the difference was significant（55.0% vs 45.5% ）（P 〈 0. 05 ）. Conclusion FHIT gene plays an improtant role in the occurrence and development of cervical carcinoma. It is suggested that FHIT can be a useful marker for predicting invasion and metastasis ability of cervical carcinoma.

关 键 词：子宫颈肿瘤 免疫组织化学 脆性组氨酸三联体基因 

分 类 号：R737[医药卫生—肿瘤]