中晚期子宫颈小细胞癌的治疗及预后分析  

Treatment and prognosis study of progressive small cell carcinoma of the cervix

作　　者：殷卓敏[1] 吴梅娟[2] 于爱军[1] 俞华[1] 

机构地区：[1]浙江省肿瘤医院妇科,杭州310022 [2]浙江省肿瘤医院病理科

出　　处：《实用肿瘤学杂志》2009年第1期29-31,41,共4页Practical Oncology Journal

摘　　要：目的研究子宫颈小细胞癌（SCCC）的治疗及预后。方法分析1997年-2005年间8例中晚期SCCC患者的临床病理资料，临床分期ⅡB期2例，ⅢA期1例，ⅢB期3例，ⅣA期1例，ⅣB期1例，根据患者病情采用根治性或姑息性治疗。采用Kaplan—Meier进行生存分析，以Log—ranktest确定统计上的显著差异。结果8例中晚期SCCC患者平均无进展生存期为20．9个月，平均总生存期为40．3个月，3年和5年生存率分别为37．5％和25％。分期越早，平均总生存期越长（P〈0．05）。8例患者中5例发生远处转移，远处转移率为62．5％。1例中心复发患者经过手术治疗继续生存92个月。结论FIGO分期是中晚期SCCC患者独立预后因素。远处转移是治疗失败的主要原因。同步放化疗能改善中晚期SCCC患者预后。对于复发患者积极的挽救治疗仍可能获得较好疗效。Objective To study the treatment and prognosis of progressive small cell carcinoma of the cervix（SCCC）. Methods 8 patients with progressive SCCC were treated from 1997 to 2005, their clinicopathologic data analyzed retrospectively. Their stages were Ⅱ B 2,ⅢA 1, ⅢB 3,ⅣA 1 and ⅣB 1. Radical cure or palliative therapy were adopted according to the pathogenetic condition of patients. Survival analysis was performed by using the Kaplan - Meier method. The statistical significance was determined by the log - rank test. Results The median FFS and OS were 20.9 month,40.3 month respectively in 8 patients with progressive SCCC patients. Survival rates for 3 years and 5 years were 37.5% and 25%, respectively. The median OS were significantly lon- ger in patients with earlier stage disease（P 〈0.05）. Conclusions FIGO staging is solitary prognostic factor for survival. Treatment mordality of concomitant chemoradiotherapy can improve prognosis. The aggressive salvage treatment was worthwhile, patients with local recurrence could be curative.

关 键 词：小细胞癌 宫颈肿瘤 治疗 

分 类 号：R737.33[医药卫生—肿瘤]