DNA甲基化作用的生物学功能  

Biological Function of DNA Methylation

作　　者：郑小梅[1] 伍宁丰[1] 

机构地区：[1]中国农业科学院生物技术研究所,北京100081

出　　处：《中国农业科技导报》2009年第1期33-39,共7页Journal of Agricultural Science and Technology

基　　金：国家863计划项目(2007AA100605)资助

摘　　要：DNA甲基化作为DNA序列的修饰方式,是一种重要的表观遗传机制,能够在不改变DNA分子一级结构的情况下调节基因组的功能,在生命活动中起着重要的作用。其功能主要可归结为以下4个方面:维持基因组遗传物质的稳定性,调控基因的表达,建立表观遗传模式以及参与细胞及胚胎的形态建成。DNA methylation, as one kind of modification way of DNA sequences, is an important epigenetic mecha- nism. It can regulate the expression of many vital genes while the base compositions of these genes do not change, therefore DNA methylation is very important to the growth and development of organism. In this paper, we summa- rized the rules of DNA methylation into four aspects, as follows ： maintaining the stability of genetic information in ge- nomes; regulating the expression of genes; establishing epigenetic patterns and participating in the development of embryos.

关 键 词：DNA甲基化 DNA甲基转移酶 表观遗传 印迹基因 X-染色体失活 

分 类 号：Q754[生物学—分子生物学]