甲羟孕酮辅助老年性肺癌化疗生存状况的临床观察  

Clinic investigation of the effectiveness of medroxyprogesterone on the survival condition of lung cancer in the elderly patients in chemotherapy period

作　　者：梁彩霞[1] 罗海涛[1] 陈振华[1] 韦习勋[1] 丘新才[1] 

机构地区：[1]南方医科大学附属南海医院.佛山市南海区人民医院,广东佛山528200

出　　处：《安徽医药》2009年第2期189-190,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察甲羟孕酮在老年性肺癌化疗期间及化疗后,对食欲、进食状况、体重、胃肠道反应以及全身情况的辅助作用。方法观察50例老年性肺癌化疗加甲羟孕酮辅助治疗病人与50例单纯化疗病人治疗期间及化疗后,食欲、食量、体重变化、胃肠道反应以及全身情况变化的比较。结果治疗组82%食欲有改善,78%食量增加,34%化疗期间无明显胃肠反应,KPS评分增加大于10分占66%。单化组食欲,食量无一例改善,仅4%无恶心、呕吐,KPS评分大于10分占6%,差异有显著性。结论甲羟孕酮辅助老年性肺癌化疗作用明显,有提高食欲,降低化疗胃肠道反应,提高生活质量的作用。Aim To study the effectiveness of medroxyprogesterone on the survival condition of lung cancer in the elderly patients in chemotherapy periods. Methods Changing of the appetite, normal food amount, weight, gastrointestinal effect and whole body conditions were observed between the chemotherapy and medroxyprogesterone group and single chemotherapy group,in which a Kamofsky performance status was adopted for evaluating the whole body conditions. Results Medroxyprogesterone could significantly improve patients＇ appetite, normal food amount, weight gain and whole body conditions for the most patients observed, while relieving the gastrointestinal effect in chemotherapy. Of the 50 patients enrolled in the chemotherapy and medroxyprogesterone group,82 percent patients had appetite improvement,78% more food amount,30% more weight gain （increment ≥0.5kg） ,34% no obvious gastrointestinal effect in the chemotherapy such as vomiting and nausea,and 66% had improved the survival condition according to the KPS score （increment ≥10） . In contrast, of the 50 patients in the single chemotherapy group, no one had improvement in the appetite and normal food amount, while only 4% had no vomiting and nausea, and 6%had improved the survival condition. The distinct differences exist between the 2 groups. Conclusion Medroxyprogesterone has quite obvious improvement in the appetite, food amount, weight gain and survival condition, while relieving the gastrointestinal effect during chemotherapy.

关 键 词：甲羟孕酮 老年性肺癌 化疗 生存状况 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]