乙肝患者血浆MBL水平分析  

Analysis of MBL Plasma Concentration of Patients with Hepatitis B

作　　者：赵铁军[1] 杨翠军[1] 侯丽娟[1] 贾天军[1] 张林西[1] 

机构地区：[1]河北北方学院实验中心,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2009年第1期41-43,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:检测健康人及乙肝患者血浆中甘露聚糖结合凝集素(MBL)水平,比较差异并评价其非特异性免疫功能。方法:采用MBL ELISA试剂盒检测健康人及乙肝患者血浆中甘露聚糖结合凝集素含量。结果:42位HBV-DNA阳性患者血浆MBL的含量为5.414±2.658mg/L,52位HBV-DNA阴性患者血浆MBL的含量为4.949±2.219mg/L,40位健康人血浆MBL的含量为2.874±1.717mg/L,HBV-DNA阳性患者与HBV-DNA阴性患者血浆MBL的含量差异无统计学意义(t=0.761,P>0.05),HBV-DNA阳性患者与健康人血浆MBL的含量差异显著(t=5.810,P<0.01),HBV-DNA阴性患者与健康人血浆MBL的含量差异显著(t=4.786,P<0.01)。结论:乙肝患者血浆MBL水平较健康人提高,说明机体分泌急性时相蛋白MBL参与机体免疫防御及监视。Objective： to investigate the concentration of mannan binding lectin of patients with Hepatitis B and further assess their innate immunity. Methods： detect the concentration of MBL with MBL ELISA kit, Results： the average of MBL plasma concentration in HBV-DNA（＋） was 5. 414：t： 2. 658mg/L,and the average of MBL plasma concentration in HBV-DNA（-） was 4. 949±2. 219mg/L, there was no statistical significence （t= 0. 761, P〉0. 05） ; the average of MBL plasma concentration in healthy was 2. 874：1：1.717 mg/L, there was statistical significance between HBV-DNA（＋） of patients and that of the healthy（t= 5. 810, P〈0. 01） ;there was statistical significance between HBV-DNA（-） of patients and that of the healthy（t=4. 786,P〈0. 01）.

关 键 词：甘露聚糖类 肝炎/乙型 肝炎病毒/乙型 

分 类 号：R575.1[医药卫生—消化系统]