缺氧诱导因子1在肝炎到肝癌演进过程中的意义  

The Role of Hypoxia Inducible Factor-1 in the Evolution from Hepatitis to Hepatocellular Carcinoma

作　　者：倪琦（综述）[1] 曾思恩[1] 谭宁（审校）[2] 

机构地区：[1]桂林医学院病理教研室,广西桂林541004 [2]桂林医学院生物技术学院,广西桂林541004

出　　处：《医学综述》2009年第5期641-644,共4页Medical Recapitulate

基　　金：广西壮族自治区研究生教育创新计划项目资助(桂学位[2008]14号);癌基因及相关基因国家重点实验室开放课题项目资助(90-08-01)

摘　　要：缺氧诱导因子1（HIF-1）是调节氧稳态的主要因子，其通过调控一系列缺氧相关基因的表达，增强肝细胞在低氧环境下的代谢适应能力，并参与肝病恶性转化的生物过程。目前研究表明，HIF-1与肝癌的发生、发展和转移有着密切的联系。鉴于肝炎是我国肝癌主要病因之一，本文对HIF—1在肝炎到肝癌演进过程中的意义进行综述。Hypoxia inducible factor-1 （HIF-1） is an essential factor to regulate oxygen homeostasis, by controling a series of hypoxia related genes expression, reinforce the metabolism adaptability of hepatic cell in the hypoxic environment and participate the biology process of liver disease malignant transformation. At pres- ent, studies have shown that HIF-1 is closely linked with the occurrence, development and metastasis of hepatocellular carcinoma. Because hepatitis is one of the major causes of hepatocellular carcinoma in our country, this article reviews the role of HIF-1 in the evolution from hepatitis to hepatocellular carcinoma.

关 键 词：缺氧诱导因子 肝炎 肝癌 

分 类 号：R575[医药卫生—消化系统]