神经生长因子及其受体在腺样囊性癌嗜神经侵袭中的作用机制  

The Contribution of Nerve Growth Factor and Its Acceptor in Adenoid Cystic Carcinoma Perineural Invasion

作　　者：骆树瑜[1] 张玉茹[1] 

机构地区：[1]天津医科大学口腔医院病理科

出　　处：《医学综述》2009年第5期688-690,共3页Medical Recapitulate

摘　　要：肿瘤周围存在通过自分泌和旁分泌方式而来的神经生长因子及受体，它们相互作用，通过激活一系列分子信号途径引起级联放大效应，导致肿瘤细胞和神经纤维相互吸引而产生神经侵袭现象。腺样囊性癌是口腔颌面部常见的恶性肿瘤，具有早期嗜神经浸润的特征性表现，这种嗜神经特性使腺样囊性癌可能沿神经播散，绐腺样囊性癌的诊断和治疗带来了极大的困难，是影响患者生存质量，引起术后复发的重要因素。因此，探讨外周神经浸润的相关机制及问题具有重要的理论和应用价值。本文就神经生长因子及其受体在腺样囊性癌嗜神经浸润中的作用及机制予以综述。Around the tumor,exist nerve growth factor and its acceptor by autocrine or paracrine. They interact, induce cascade amplification effect by activating a series of cell signals, lead to inter-attraction between tumor cells and neural fibers, appear the perineural invasion phenomenon. Adenoid Cystic Carcinoma is a common malignant tumor in oromaxillo-facial region, has the manifestation with early perineural invasion, which may make adenoid cystic carcinoma to spread along nerve, give the difficulty to diagnose and treatment of adenoid cystic carcinoma,influence the life quality of patients, cause post-operation palindromia. Accordingly ,to investigate the correlated mechanism and questions has important value in theory and application. This article reviews the contribution and mechanism of nerve growth factor and its acceptor in adenoid cystic carcinoma perineural invasion.

关 键 词：涎腺腺样囊性癌 嗜神经浸润 神经生长因子及其受体 

分 类 号：R739.81[医药卫生—肿瘤]