脑梗死患者血浆纤维蛋白原与颈动脉内-中膜层厚度和梗死面积的关系  

Relationship between plasma fibrinogen and carotid intima-medial thickness and infarction area

作　　者：翟国杰[1] 邵国富[1] 黄平[1] 刘瑞杰[1] 

机构地区：[1]苏州大学附属第二医院神经内科,215004

出　　处：《神经疾病与精神卫生》2008年第6期436-437,共2页Journal of Neuroscience and Mental Health

摘　　要：目的分析血浆纤维蛋白原水平与颈动脉内-中膜厚度和梗死面积的关系。方法对163例脑梗死患者行颈动脉超声检查,记录每例受检者双侧颈总动脉（common carotid artery,CCA）内-中膜厚度（Inti ma-medial Thickness,I MT）,抽取入院后24h内空腹静脉血3-4ml送检,测定纤维蛋白原水平。先依据颈动脉内-中膜厚度分为A组（〈1.2mm）和B组（≥1.2mm）,然后再按梗死面积大小分成两组（较大面积脑梗死组和腔隙性脑梗死组）,比较两组血浆纤维蛋白原水平的差异。结果B组血浆纤维蛋白原水平明显高于A组（P〈0.05）;腔隙性梗死患者纤维蛋白原水平高于较大面积脑梗死组。结论血浆纤维蛋白原水平和颈动脉内-中膜厚度明显相关,可能是颈动脉内-中膜增厚的危险因素;腔隙性梗死患者的发病与血浆纤维蛋白原水平密切相关。Objective To investigate the relationship between plasma fibrinogen and carotid intima -medial thickness and the area of infarction. Methods Ultrasonographic scanning of the bilateral common carotid arteries of 163 patients was performed, rotid artery of each patient examined was measured. hours after hospitalization, by using 3 - 4 ml blood and the intima-medial thickness of the common carotid artery of each patient examined was measured. The levels of plasma fibrinogen were measured in 24 hours after hospitalization, by using 3-4 ml blood sample extracted trom veto under limosis, llne patients were firstly divided into A group （intima-medial thickness〈1. 2 mm） and B group （intima-medial thickness≥1. 2 mm） based on the intima-medial thickness; and then depending on the area of infarction, all the patients were again divided into two groups （cerebral infarction group of larger area and lacunar infarction group）. The difference of the levels of plasma fihrinogen in the groups was separately analyzed. Results Plasma fibrinogen in B group was higher than that in A group （P 〈 0.05）, and plasma fibrinogen in lacunar infarction patients was higher than that in cerebral infarction group of larger area. Conclusions The levels of plasma fibrinogen are associated with carotid intima-medial thickness, and may be a risk factor for increasing the thickness of carotid intima-medial film. And the occurrence of lacunar infarction among the patients is closely related to the level of plasma fibrinogen.

关 键 词：纤维蛋白原 颈动脉 内-中膜厚度 脑梗死 梗死面积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]