人肝细胞癌及癌周组织内P^(53)蛋白表达的研究  

Expression of P^(53) protein in hepatollular carcinoma and its surrounding tissues

作　　者：邹伟[1] 张昭成[1] 牛兆山[1] 周颖斌[2] 

机构地区：[1]青岛医学院病理学教研室,266021 [2]青岛医学院生理学教研室,266021

出　　处：《肿瘤防治研究》1998年第1期1-2,共2页Cancer Research on Prevention and Treatment

基　　金：山东省教委科研基金!J94K26

摘　　要：应用LSAB免疫组化方法检测73例原发性肝细胞癌（HCC））及其癌旁组织中P53蛋白的异常表达。结果显示：P53蛋白在HCC中阳性表达率显著高于癌旁组织，且与HCC分化程度呈显著正相关，低分化组P53蛋白阳性表达率显著高于高分化组（P＜0．05）；癌旁组织中，p53蛋白表达仅见于增生结节中，肝硬化组织内未见p53蛋白阳性表达。提示P53基因突变是HCC的频发事件，在HCC的发生发展中发挥重要作用；增生结节是HCC的癌前病变。The expression of P53 protein was examined in 73 cases of hepatocellular carcinoma (HCC) and its surrounding tissues with LSAB immunohistochemical technique. The results showed that positive expression of P53 in HCC was significantly higher than that in surrounding tissues, and correlated with histological differentation,P53 positive rate in poor differentation was higher than that in well differentation (P< 0. 05 ). In surroun-d- ing tissues, p53 protein expression was only in liver hyperplastic nodule(LHN), not in liver cirrhosis(LC). Suggesting that mutation of P53 gene is frequent and correlated with progression of HCC; LHN is preneoplasia lesions of HCC.

关 键 词：肝肿瘤 P53 肝细胞癌 免疫组织化学 

分 类 号：R735.702[医药卫生—肿瘤]