鼻咽癌组织VEGF-C和VEGFR-3表达与临床病理因素相关性分析  

Expressions of VEGF-C,VEGFR-3 and LVD in nasopharyngeal carcinoma and their relation to clinicopathologic characteristics

作　　者：肖芸[1] 李金高[1] 黄传生[1] 敖凡[1] 叶建明[1] 

机构地区：[1]江西省肿瘤医院放疗科,江西南昌330029

出　　处：《中华肿瘤防治杂志》2008年第22期1724-1727,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨鼻咽癌(NPC)组织VEGF-C和VEGFR-3的表达,及其和淋巴管密度(LVD)与临床病理参数的关系。方法:采用免疫组织化学PV-9000二步法检测55例NPC患者放疗前活检组织石蜡标本中VEGF-C和VEGFR-3的表达及LVD,分析其与临床病理参数之间的关系。结果:NPC无淋巴结转移组VEGF-C阳性率(61.5%)低于淋巴结转移组(89.7%),P=0.01;无淋巴结转移组VEGFR-3阳性率(73.0%)低于淋巴结转移组(89.7%),P=0.011;无淋巴结转移组LVD(15.2±5.2)低于淋巴结转移组(19.3±6.6),P=0.013。VEGF-C和VEGFR-3的表达与临床分期有关,P<0.001;而VEGF-C和VEGFR-3的表达及LVD与年龄、性别和原发肿瘤T分期无关,P>0.05。VEGF-C和VEG-FR-3均与LVD呈正相关,r值分别为0.491和0.467,P值均为0.000。结论:VEGF-C可促进淋巴管生成和NPC颈淋巴结转移。针对VEGF-C/VEGFR-3信号传导系统的抗淋巴管生成的治疗,有望成为抗NPC淋巴结转移的有效途径。OBJECTIVE： To detect the expressions of VEGF-C and VEGFR-3, and LVD in biopsy specimens of nasopharyngeal carcinoma （NPC） before radiotherapy and investigate their associations with clinico- pathologic characteristics. METHODS： The expressions of VEGF-C and VEGFR-3, and LVD in paraffin embedded specimens from 55 cases of NPC were studied with PV 9000 immunohistoehemical staining, as well as their relations to elinicopathologie characteristics were analyzed. RE- SULTS： The positive rates of VEGF-C were 61.5% and 89. 7% in the node negative group and node positive group respectively, and there was a significant difference between them （P = 0.01 ）. The positive rates of VEGFR-3 were 73.0~//00 and 89. 7% respectively in the two groups, and there was a significant difference between them （P ~ 0. 011 ）. The mean LVD in the node negative group（15.2±5.2） was lower than it （19.3± 6.6） in the node positive group（P=0. 013）. The expressions of VEGF-C and VEGFR-3 were significantly lower in the stageⅠ,Ⅱgroup than those in the stage Ⅲ, Ⅳ group （P〈0. 001）, whereas the expressions of VEGF-C and VEGFR-3 and LVD were not related to age, sex or clinical T stages （P〉0.05）. With the increase of the expressions of VEGF-C and VEG- FR3, LVD increased and there were significant differences among the dif- ferent VEGF-C or VEGFR-3 groups. Positive correlations were also ob- served between the expression of VEGF-C or VEGFR-3 and LVD by Spearman correlation analysis （rs = 0. 491, P = 0. 000; rs= 0. 467, P =0. 000）. CONCLUSION： The binding of VEGF-C and its specfie receptor, VEGFR-3 could promote lymphangiogenesis and node metastasis in NPC. Chin J Cancer Prev Treat ,2008,15（22）：1724--1727

关 键 词：鼻咽肿瘤 血管内皮生长因子C 血管内皮生长因子受体-3 淋巴管密度 

分 类 号：R739.63[医药卫生—肿瘤]