二甲亚砜和维甲酸对人卵巢癌细胞COC1的生长抑制和超微结构的影响  

The Growth Inhibition and the effects of ultrastructure of DMSO and RA on Human Ovarian Cancer Cell COC1

作　　者：李从荣[1] 李爱林[1] 姚学军[2] 陈敏诲[2] 

机构地区：[1]湖北医科大学附属第一医院,武汉430060 [2]湖北医科大学细胞生物室

出　　处：《肿瘤防治研究》1998年第1期17-19,共3页Cancer Research on Prevention and Treatment

摘　　要：本实验以人卵巢癌细胞株COC1为模型，观察了诱导分化剂二甲亚砜（DMS0）与维甲酸（RA）对该细胞生长增殖及超微结构的影响。结果表明，DMSO和RA可明显抑制COC1细胞的生长，并改变其恶性细胞的结构特征，使之向正常细胞的方向逆转，从而提示DMSO和RA对人卵巢癌细胞有一定的诱导分化作用。The first affiliated hospital of Hubei MedicalThe effects of DMSO and RA on cell growth and ultrastructure in the cell werestudied by using ovarian cancer cell COC1 as a model. The results showed that the proliferation of COC1 cells was significantly inhibited by DMSO or RA, DMSO or RA canchange the structural characteristic of COC1 cell from malignant state to differentiatedone. It suggest that DMSO and RA have the ability to induce differentiation of humanovarian cancer cell.

关 键 词：二甲亚砜 维甲酸 诱导分化 卵巢肿瘤 癌细胞 

分 类 号：R73－36[医药卫生—肿瘤] R737.310.5[医药卫生—临床医学]