丹参、心得安对门静脉高压症大鼠门静脉压力和胃肠激素的影响  

Influence of Dan-shen and propranolol dinitrate on portal venous pressure and gastrointestina hormone in rats with portal hypertension

作　　者：李民[1] 顾尔莉[1] 章幼奕[1] 窦志华[1] 罗琳[2] 徐济良[2] 陈鸣鸣[1] 陈淑范[1] 葛春霞[1] 朱浩然[1] 

机构地区：[1]南通大学附属南通第三医院肝病科,江苏南通226006 [2]南通大学医学院

出　　处：《中西医结合肝病杂志》2009年第1期36-38,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：江苏省南通市社会发展科技计划资助项目(No.S40019)

摘　　要：目的:观察丹参、心得安对门脉高压症大鼠门静脉压力、胃肠激素的影响。方法:采用CCl4加酒精饮料制作大鼠门脉高压模型,造模4周后分别给大鼠服用丹参、心得安,造模结束后用Medlab-Ug4Cs生物信号采集处理系统检测正常组、模型组、丹参治疗组、心得安治疗组大鼠门静脉压力。处死大鼠后颈动脉取血,用放免法检测4组大鼠血浆胃肠激素(胃动素、胃泌素、胰高血糖素)的含量。结果:模型组大鼠门静脉压力较正常组明显升高(P<0.01),丹参治疗组、心得安治疗组大鼠门脉压力较模型组明显下降(P<0.01),丹参治疗组大鼠门脉压力与心得安治疗组比较差异无显著性意义(P>0.05)。心得安组大鼠与模型组比较胃动素含量无明显改善(P>0.05),而胃泌素、胰高血糖素明显下降(P<0.05)。丹参治疗组大鼠胃泌素、胃动素、胰高血糖素含量与模型组比较明显下降(P<0.01或P<0.05),与心得安治疗组比较,胃动素、胰高血糖素指标下降明显(P<0.05)。结论:丹参能有效降低门脉高压症大鼠门静脉压力,调节胃肠激素,疗效优于心得安治疗组。其作用机制可能与其良好的抗肝纤维化、阻止肝硬化形成、调节胃肠激素水平、改善肝功能等作用有关。Objective： To observe the influence of Dan-shen and propranolol dinitrate on portal venous pressure and gastrointestinal hormone in rats with portal hypertension. Methods： To develop the portal hypertension model, rats were feeded with the drink include CCI4 and alcohol. After four weeks, The rats were dosed with Dan-shen, propranolol dinitrate respectively. Portal venous pressure were measured in control group, model group, Dan-shen group, propranolol dinitrate group respectively. Then put the rats to death and collect neck arterial blood for experiments. The concentration of gastrointestinal hormone were detected by radioimmunoassay respectively. Results： The portal venous pressure in model group were higher than that of the control group obviously （P 〈0. 01 ） ; The portal venous pressure in Dan -shen and propranolol dinitrate group were lower than thot of the model group obviously （P 〈 0.01 ） ; The portal venous pressure in Dan -shen group showed no significant differemce from that of the propranolol dinitrate group （ P 〉 0. 05 ） . The concentration of motilin in propranolol dinitrate group showed no significant difference from that of model group （ P 〉 0. 05 ） , but the concentration of gastrin, glucagon was lower than that of model group obviously （P 〈 0. 05 ） . In Dan-shen group, the concentration of gastrin, motilin, glucagon were lower obviously than that of model group （P 〈 0.01 or P 〈 0. 05 ）, as well as obviously lower than model group （ P 〈 0. 05 ） . Conclusion： Dan-shen can effectively reduce the portal venous pressure, just the concentration of gastrin, motilin, glucagon in rats with portal hypertension, which was superior to the propranolol dinitrate group.

关 键 词：丹参/药理作用 心得安/药理作用 胃肠激素 门脉高压 

分 类 号：R575.2[医药卫生—消化系统]