涎腺肿瘤与癌基因c-myc抑癌基因p53和人类乳头状病毒感染的关系  

Tbe relationship among salivary gland tumour and overexpression of oncogene c-myc, tumour suppressor gene p53, infection of human papillomavirus

作　　者：陈建钢[1] 范崇德[1] 李清[1] 贺小玲[1] 喻伦银[2] 毛永荣[3] 

机构地区：[1]湖北医科大学附二医院,430071 [2]湖北医科大学病理解剖教研室 [3]湖北省肿瘤医院病理科

出　　处：《现代口腔医学杂志》1998年第1期12-14,共3页Journal of Modern Stomatology

摘　　要：本实验采用免疫组化、PCR技术和核酸电泳方法,对涎腺多形性腺瘤和其它类型良恶性肿瘤进行对比研究,结果显示:在涎腺多形性腺瘤中,c-myc和p53阳性率分别为50％(10/20)和25％(5/20,均远低于涎腺恶性肿瘤阳性率100％(3/3),提示c-myc表达与涎腺上皮细胞增殖速度加快有关,其表达率升高,与细胞癌变有密切联系。p53阳性表达率,虽在恶性肿瘤较高,但仅为判断细胞分化程度的一个参考指标。关于腮腺肿瘤与HPV关系,15例多形性腺瘤和3例腮腺癌中,HPV6.11均为阴性,HPV16.18阳性反应各为1例(1/5和1/3),远远低于HPV16.18在口腔肿瘤中的感染率,考虑到腮腺与口腔组织所处环境差异(后者易受烟草刺激),HPV16.18的致癌作用,主要表现为协同关系。In this study, salivary gland pleomorphic adenomas and other salivary gland, tumours were investigated comparatively, by means of immunohistochemical methed, PCR and nuclear electrophoresis. The results show: The positive stained rates of c-myc and p53 were 50 % (10 /20 )and25%(5 /20 ). repeately: These rates were lower than those of malignant tumours of salivary gland 100% (3/3). The investigation suggested thai c-myc over expression was associated with cell proliferating cycle and cell mutation. p53 positive rate was only a reference date for tumour cell grouth and differnitiation, though it was high in malignant tumours. In 15 cases of pleomorphic adenoma and 3 cases of parotid gland carcinoma, HPV6. 11 stain reaction were all negative, but HPVI6.18 stained case was 1(11/15 and 1/3)repeatively, These were lower than HPVI6.18 infections rate of oral tumour. Considering environments between parotid gland and oral cavity, the authors indicate carcinogenesis of HPV16.18 is in their co-operation.

关 键 词：涎腺肿瘤 P53 人乳头状瘤病毒 癌基因 C-MYC 

分 类 号：R739.870.2[医药卫生—肿瘤]