顺铂与卡铂为主的联合化疗疗效及毒副反应的比较研究  

Comparative study of effects and toxicities of combined chemotherapy mainly with cisplatin and carboplatin

作　　者：叶茂昌[1] 王来平[1] 李容新[1] 吴冰[1] 武瑾[1] 洪礼琳[1] 罗永祥[1] 刘青[2] 鲍秀芳 

机构地区：[1]安徽省立医院口腔颌面外科,230001 [2]检验科

出　　处：《现代口腔医学杂志》1998年第1期40-42,共3页Journal of Modern Stomatology

基　　金：安微省科委资助课题

摘　　要：作者近十年间行金属铂诱导化疗84例,其中顺铂+平阳霉素+长春新碱(PVP)组53例;卡铂+平阳霉素+长春新碱(CVP)组31例。治疗结果:PVP和CVP方案的近期疗效相接近,总有效率分别是86.79％和77.41％,两组差异无显著意义。毒副反应的比较表明:PVP以肾毒性、胃肠毒性和耳毒性为主,发生率分别为13.2％、79.24％和11.32％;而CVP则以骨髓毒性和肝毒性为特征,分别为38.70％和12.90％。两组分别出现的毒副反应及其并发症尚未影响诱导化疗的使用。A randomied study on 84 patients with induction chemotherapy was performed. 53 patients were in group of cisplatin, VCR and PYM(PVP). 31 patients were in groud of carboplatin. VCR and PYM (CVP). Over-all response rates were 86.79 % and 77.41% respectively, there was no statistically difference. Chemotherapy toxicities of two groups were compared. In PVP group there were mainly nephrotoxicity. gastrointestinal toxicity and ototoxicity. The incidences of them were 13.2%, 79.2% and 11.32% respectively. The toxicities of CVP were mainly myelotoxicity ( 38. 70 % ) and hepatotoxicity ( 12.90% ). The authors conclued the toxicities of two groups were clinically acceptable.

关 键 词：口腔粘膜肿瘤 鳞癌 药物疗法 顺铂 卡铂 

分 类 号：R739.850.5[医药卫生—肿瘤] R730.53[医药卫生—临床医学]