内胚窦瘤临床病理及免疫组织化学研究(附40例报告)  

CLINICOPATHOLOGIC AND IMMUNOHISTOCHEMICAL STUDY OF ENDODERMAL SINUS TUMOR (REPORT OF 40 CASES)

作　　者：郑河川[1,2] 刘现军[1,2] 

机构地区：[1]河北省邯郸市第一医院病理科 [2]邯郸医专病理科

出　　处：《河北医科大学学报》1998年第1期11-13,共3页Journal of Hebei Medical University

摘　　要：目的：探讨内胚窦瘤的病理学特点。方法：采用常规病理技术及免疫组织化学方法，研究４０例内胚窦瘤患者，其中３２例发生于卵巢，８例发生于睾丸。结果：组织学表现有５种，网状结构、透明小体、腺样结构、内胚窦样结构和实体状结构，前３种可作为诊断标准。免疫组织化学染色结果：兔抗人单克隆甲胎蛋白（ＡＦＰ）、抗胰蛋白酶（ＡＡＴ）均为阳性，绒毛膜促性腺激素（ＨＣＧ）和癌胚抗原（ＣＥＡ）均为阴性。结论：不同的组织结构特征及免疫组织化学表现，有助于对内胚窦瘤的诊断。Objective:To explore pathological charateristics of endodermal sinus tumor.Methods:Forty cases of endodermal sinus tumor,among which 32 cases originated from ovary and 8 cases testis,were studied with routine pathological technique and immunohistochemical method.Results:According to tissue origin,they were divided into five classes:reticular pattern,hyaline body,glandlike structrue,ShillerDural (SD) body,and solid formation.The former three kinds were thought to be the main diagnostic criteria.40 cases were observed by immunohistochemical methods.Positive immunostaining for AFP and AAT were found in all of these cases.Neither HCG nor CEA was identified in all these cases.Conclusion:Different characteristics of tissue structure and immunohistology may provide helpful clues for diagnosis of endodermal sinus tumors. 

关 键 词：内胚窦瘤 病理 免疫组织化学 卵巢肿瘤 睾丸肿瘤 

分 类 号：R737.310.2[医药卫生—肿瘤] R737.210.2[医药卫生—临床医学]