咖啡因对大鼠杏仁核点燃模型的作用研究  

Study on the Effect of Caffeine on Amygdala Kindled Models

作　　者：韩庆方[1] 王蕾[1] 杨丽卿[1] 梁瑜[1] 杨雪[1] 岳旺[1] 

机构地区：[1]青岛大学医学院药理学教研室,山东青岛266021

出　　处：《现代生物医学进展》2009年第4期715-717,共3页Progress in Modern Biomedicine

摘　　要：目的:观察兴奋药咖啡因对点燃癫痫模型的作用。方法:建立大鼠杏仁核点燃模型,观察不同剂量的咖啡因及与抗癫痫药物联用对杏仁核点燃大鼠的后放电时程(ADD)和Racine's分级的影响。结果:咖啡因提高点燃大鼠的ADD,但联用抗苯妥英钠和苯巴比妥可降低ADD(P<0.01)及Racine's分级(P<0.01)。结论:小剂量的咖啡因与抗癫痫药物能产生协同作用。Objective： To investigate the effect of caffeine on amygdala kindling models in rats. Methods： A model of chomic eplipsy kindled by electric stimulation of the right amygdala with constant electric current was set up successfully in the male Wistar rats. The kindled rats were given the drugs by ip injection in order to investigate their effects on kindling seizure. Results： The combination of caffeine with anti-epilepsy drugs inhibited the amygdala kindled seizure, shorten the ADD （P〈0.01） and reduce Racine＇s stages （P〈0.01）. Conclusions： Caffeine and anti-epilepsy drugs have synergistic effects on kindling models.

关 键 词：咖啡因 点燃模型 抗癫痫药 协同作用 

分 类 号：R971.6[医药卫生—药品]