基于盒子维的帕金森病苍白球损毁术神经组织定位  

The Box-dimension-based Localization of Neuronal Structures in Pallidotomy for Treatment of Parkinson's Disease

作　　者：刘新文[1,2] 钱志余[1] 王惠南[1] 杨天明[3] 李昆山[2] 

机构地区：[1]南京航空航天大学自动化学院生物医学工程系,南京210016 [2]防空兵指挥学院信息控制系,郑州450052 [3]东南大学附属中大医院神经外科,南京210009

出　　处：《生物医学工程学杂志》2009年第1期167-172,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30371362)

摘　　要：目前临床帕金森病苍白球损毁术中,主要依靠医生观察微电极记录的神经电生理信号,凭经验主观定性地对微电极定位。利用分形盒子维方法进一步分析神经放电信号的特征,获取不同位置微电极信号的盒子维数定位因子,实现微电极所在神经组织的识别。通过统计分析临床大量的神经放电数据分形盒子维,给出了神经组织定位方法。经临床病例和专家验证,此方法可以提高定位精度并可用于临床中引导手术。Currently, the intraoperative location of microelectrode position in the globus pallidus is subjective and qualitative; it only depends on the experience of doctors during pallidotomy for the treatment of Parkinson＇s disease. The fractal characteristic of neuronal discharge signals is analyzed for target localization; the factor of box di- mension is extracted from the microelectrode recordings for identifying the neuronal structures at the depth of micro- electrode. New objective and quantitative targeting technique is presented by processing clinical microelelctrode re- cordings of Parkinson^s disease. Through the validation of clinical data and the critical appraisal by experts, the tar- geting technique can be used for improving the accuracy of localization in neurosurgery.

关 键 词：微电极定位 盒子维 帕金森病 微电极记录 

分 类 号：R742.5[医药卫生—神经病学与精神病学]