c-Met和TIMP-2在喉癌中的表达及其意义  

Expression and their significance of c-Met and TIMP-2 in laryngeal squamous cell carcinoma

作　　者：郑娟[1] 黎万荣[2] 

机构地区：[1]山东省淄博市桓台县人民医院耳鼻咽喉科,山东淄博256400 [2]泸州医学院附属医院耳鼻咽喉头颈外科,四川泸州646000

出　　处：《中国耳鼻咽喉头颈外科》2009年第2期88-91,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的检测c-Met、TIMP-2蛋白在喉鳞状细胞癌(简称喉癌)及癌旁组织中的表达水平,研究两者表达与临床、病理参数的关系,探讨两者在喉癌侵袭、转移过程中的作用及其两者的相互关系。方法选取喉癌患者41例,另选癌旁组织15例作为对照,采用免疫组织化学方法(SP法)检测c-Met、TIMP-2的表达。结果c-Met、TIMP-2蛋白在喉癌组织中的阳性率分别为56.1%(23/41)及63.4%(26/41)。c-Met蛋白在癌旁组织中的阳性率为13.3%(2/15),TIMP-2蛋白在癌旁组织为阴性。结论c-Met与喉癌颈淋巴结转移及病理分级有关;TIMP-2与喉癌的颈淋巴结转移有关;c-Met与TIMP-2在喉癌中的表达无相关性。OBJECTIVE To study the expression of c-Met, TIMP-2 in laryngeal squamous cell carcinoma and to explore the function and relationship of c-Met, TIMP-2 in the invasion and metastasis of laryngeal squamous cell carcinoma. METHODS Immunohistochemical method （SP） was used to detect the expression of c-Met, TIMP-2 in 41 laryngeal squamous cell carcinoma specimens and 15 specimens adjacent to the tumors. RESULTS The positive rate of c-Met and TIMP-2 in laryngeal squamous cell carcinoma specimens was 56.1% （23/41） and 63.4% （26/41） respectively. The positive rate of c-Met in tissues adjacent to tumors was 13.3% （2/15） . No positive expression of TIMP-2 was found in tissues adjacent to tumors. CONCLUSION The expression of c-Met showed a positive correlation with histological differentiation and cervical lymph node metastasis and TIMP-2 showed a positive correlation with cervical lymph node metastasis in laryngeal squamous cell carcinoma. There was no significant relation between the expression of c-Met and TIMP-2 in laryngeal squamous cell carcinoma.

关 键 词：原癌基因蛋白质c—met 金属蛋白酶类组织抑制剂 喉肿瘤 癌 鳞状细胞 免疫组织化学 

分 类 号：R739.6[医药卫生—肿瘤]