生姜油预防日本血吸虫尾蚴感染的实验研究  

Preventive Effect of Ginger Oil against the Infection Caused by Schistosoma japonicum cercariae

作　　者：边藏丽[1] 夏鹏[1] 黄柏青[1] 金露萍[1] 李巧[1] 

机构地区：[1]长江大学医学院,湖北荆州434000

出　　处：《时珍国医国药》2009年第2期282-283,共2页Lishizhen Medicine and Materia Medica Research

基　　金：湖北科技攻关计划资助项目(No.2006AA402C51)

摘　　要：目的探讨生姜油预防日本血吸虫尾蚴感染的效果以及对皮肤的毒副作用。方法将实验小鼠随机分为A、B、C3组,先将生姜油涂抹于A、B组小鼠皮肤,A组小鼠直接用血吸虫尾蚴感染,B组小鼠用泥浆水洗擦后感染血吸虫尾蚴,C组为对照组,A、B两组结果与对照组比较,观察生姜油预防血吸虫尾蚴感染的效果。另以生姜油涂于小鼠腹部,观察对皮肤的毒副作用。结果A组小鼠血吸虫尾蚴的感染率为0,减虫率达100%;B组小鼠感染率为10%,减虫率达88.5%;两组结果与对照组比较血吸虫尾蚴感染率差异均有显著统计学意义(P<0.001)。小鼠皮肤涂生姜油后未见异常反应。结论生姜油涂肤有防御日本血吸虫感染的作用;对皮肤无明显毒副作用。Objective To investigate the preventive effects of Ginger oil against the infection caused by Schistosoma japonicum cercariae and its toxic and side effects to skin. Methods The mice were divided into Ginger oil group （group A） , muddy water group （group B） and control group （group C） at random. Ginger oil was besmeared on the skin of mice and then the mice were either directly infected with Schistosoma japonicum cercariae （group A） or with the Schistosoma japonicum cercariae after washed by muddy water （ group B）. Meanwhile, Ginger oil was besmeared on the abdomen of mice to observe its toxic and side effects to skin. Results None was infected in the Ginger oil group, the infection percentage of the muddy water group was 10%, and the rates of worm reduction were 100% and 88.5%, respectively. There were significant differences among the Ginger oil group, the muddy water group and the conorol group （P 〈0. 001 ）. In addition, no obvious injury was observed on the skin of mice when treated with Ginger oil. Conclusion Ginger oil has significant protective effect against infection caused by Schistosoma japonicum cercariae with little toxic and side effect.

关 键 词：生姜油 日本血吸虫 尾蚴 小鼠 

分 类 号：R383.24[医药卫生—医学寄生虫学]