S100A4和MMP-2在胃癌组织中的表达及与侵袭和转移的关系  

Expressions of S100A4 and MMP-2 and their relationships with invasive and metastatic potential in gastric cancer

作　　者：程慧[1] 汪素文[2] 曲飞[3] 田斌[4] 

机构地区：[1]山东大学医学院,山东济南250012 [2]济南市中心医院消化内科,山东济南250013 [3]济南市中心医院病理科,山东济南250013 [4]济南市中心医院普外科,山东济南250013

出　　处：《中国现代普通外科进展》2009年第1期35-38,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:通过检测S100A4、基质金属蛋白酶2(matrix metalloproteinase 2,MMP-2)在胃癌组织中的表达,探讨其在胃癌转移中的作用。方法:应用免疫组织化学方法检测S100A4和MMP-2在正常胃黏膜(n=20)、胃癌组织(n=49)中的表达,比较二者在两种组织中的表达差异。结果:S100A4、MMP-2在胃癌组织中的阳性表达率分别为59.18%、67.35%,其染色强度随浸润深度、淋巴结转移和肿瘤分期的增加而增强(P<0.05);在胃癌的不同病理类型和分化程度亚组,S100A4和MMP-2的表达差异均无统计学意义(P>0.05);S100A4在正常胃黏膜组织不表达,MMP-2在正常胃黏膜组织中的表达率为20.00%,两者的表达率均显著低于胃癌组织中的表达率(P<0.01)。S100A4和MMP-2在胃癌组织中的表达呈正相关(r=0.661,P<0.001)。结论:S100A4、MMP-2在肿瘤侵袭转移中发挥了重要作用,联合检测S100A4和MMP-2的表达可用于评定胃癌的转移潜能。Objective：To investigate the expressions of S100A4 and MMP- 2 and their correlations to invasiveness and metastasis in gastric cancer. Methods：The expressions of S100A4 and MMP- 2 were detected by SP immunohistochemical method in 49 cases of gastric cancer tissue and 20 cases of normal tissue. Results：The positive rate of S100A4 and MMP- 2 （59.18% 、67.35%） was significantly higher in gastric cancer tissue than in normal gastric tissue （0.00% 、20.00% ,P〈0. 001）. The intensity of S100A4 and MMP- 2 staining in tumor cells was correlated significantly with depth of tumor infiltration（T- stage）, lymph node metastasis（N- stage）and TNM stage. No significant correlations were found between S100A4 and MMP- 2 with tumor differentiation and histologic types.There was a positive relationship between the expression of S100A4 and MMP- 2（r=0.661, P〈0.001）. Conclusion： S100A4 and MMP- 2 proteins play a critical role in tumor metastasis. Codetection of the expression of S100A4 and MMP- 2 can be used to evaluate the metastatic potential of gastric cancer.

关 键 词：胃肿瘤 肿瘤侵润 肿瘤转移 S100A4 基质金属蛋白酶类 

分 类 号：R737.9[医药卫生—肿瘤]