剂量限制模板在早期鼻咽癌调强放疗计划中的应用研究  

A application study of dose constraint template in intensity modulated radiation therapy planning for early stage nasopharyngeal carcinoma

作　　者：胡炜[1] 于长辉[1] 邵明海[1] 杨海华[1] 丁维军[1] 杨伟芳[1] 单国平[1] 吴式琇[2] 

机构地区：[1]浙江省台州医院放疗科,临海317000 [2]温州医学院附属第一医院放疗科

出　　处：《中华放射医学与防护杂志》2009年第1期61-64,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：浙江省科学技术厅重大与高发疾病防治技术项目基金资助（2007C13054）

摘　　要：目的研究早期鼻咽癌患者调强放疗计划中应用剂量限制模板提高计划靶区适形度和缩短调强计划优化时间。方法10例接受调强放疗的早期鼻咽癌患者，利用Corvus6．3调强治疗计划系统勾画靶区，并在计划靶区外加剂量限制区。设计3种治疗计划：既没有剂量限制区也没有剂量限制模板的常规计划（Pian0）、没有剂量限制区而有剂量限制模板的计划（Plan1）、两者都有的计划（Plan2），并比较它们在计划靶区和正常组织的剂量分布。结果三者比较，靶区和正常组织的剂量分布均满足要求，差异无统计学意义；但Plan2中靶区适形度较另外2种计划明显提高，并显著地缩短了治疗计划完成的时间。结论早期鼻咽癌调强放疗计划中应用含有剂量限制区的剂量限制模板的方法可以提高计划靶区适形度，并明显缩短计划时间，提高制定治疗计划的效率。Objective To investigate a feasibility of using dose constraint template （DCT） to increase conformity index （CI） of planning target volume （PTV） and improve intensity modulated radiation therapy （IMRT） planning efficiency for early stage nasopharyngeal carcinoma. Methods Ten patients with pathological diagnosed and treated by IMRT were selected for this study. Target volumes were delineated with Corvus 6.3 of treatment planning system, two dose limiting regions（DLR） around PTV were added by extending from PTV, each DLR was 1 cm thick. We created three plans：Plan0,Planl and Plan2. PianO was without DLR and DCT, Planl without DLR but with DCT, Plan2 with both condition; but to compare dose distribution in PLTV and normal tissue using three plans. Results Three plans could fill equal request of dose distribution in PLTV and normal tissue, and their difference was not statistical significant. CI of Plan2 was increased and planning time was decreased significantly compared with PianO and Planl. Conclusion Usage of DCT together with DLR can increase CI of PTV and improve IMRT planning efficiency for early stage nasopharyngeal carcinoma, planning time is shortened significantly.

关 键 词：鼻咽肿瘤 放射疗法 调强适形 剂量限制 剂量模板 

分 类 号：R739.63[医药卫生—肿瘤] R979.1[医药卫生—临床医学]