儿童急性髓系白血病临床研究  

Clinical study of childhood acute myelogenous leukemia

作　　者：赵新民[1] 胡亚美[1] 臧晏[1] 刘世颖[1] 耿兰增[1] 吴敏媛[1] 张永红[1] 石慧文[1] 郑胡镛[1] 赵辉[1] 

机构地区：[1]首都医科大学附属北京儿童医院

出　　处：《中华血液学杂志》1998年第1期6-9,共4页Chinese Journal of Hematology

摘　　要：目的：了解儿童急性髓系白血病的临床特点、治疗疗效及预后因素。方法：对１９７８年８月～１９９５年１２月２７４例儿童急性髓系白血病进行临床总结和分析。结果和结论：中位确诊年龄７岁３个月，男∶女＝１．６３∶１，Ｍ２、Ｍ３型占８０％，高白细胞血症２０例，髓外白血病２４例，有Ａｕｅｒ小体者占３２．９％。治疗２４４例，分别以三种方案进行治疗，完全缓解（ＣＲ）率５５．８８％～９２．３１％，证明采用ＤＡ或ＤＡ＋Ｖｍ２６或Ｖｐ１６是提高ＣＲ的关键。影响诱导缓解因素为病初白细胞计数和肝脾肿大程度。通过ＳＰＳＳ统计学软件分析，ＡＭＬ亚型、Ａｕｅｒ小体、诱导缓解时间、髓外白血病等因素对远期预后有影响。Objective:To investigate the clinical characteristics,treatment responsiveness and prognostic factors of childhood acute myelogenous leukemia.Methods:Two hundred and seventyfour children with acute myelogenous leukemia diagnosed between 1978 and 1995 were retrospectively analyzed.Results and conclusions:Male∶female is 1.6∶1.The median age was 7.25 years. M2 and M3 were the commonest subtypes( 80%).Twenty cases were hyperleukocytosis and 24 with extramedullary involvement.Thirty two percent of the patients was Auer rods positive.Two hundred and fortyfour patients received combination chemotherapy.Complete remission(CR) rates varied from 55.88% to 92.31%.Intensive chemotherapy(including DA,DA+Vm26 or Vp16) was the cornerstone for high CR rate.Other factors influencing CR rate were initial WBC count and hepatosplenomegaly.

关 键 词：白血病 急性 髓系白血病 临床研究 儿童 

分 类 号：R733.71[医药卫生—肿瘤]