胃肠道恶性肿瘤术后腹腔热灌注联合全身化疗的疗效观察  

Intraperitoneal hyperthermai chemotherapy combined with general chemotherapy after surgery for malignant gastrointestinal tumors

作　　者：曹军丽[1] 胡宗兰[1] 付占昭[1] 顾涛[1] 程少会[1] 华海侠[1] 杨森[1] 张丽娇[1] 杨雁鸿[1] 董立新[1] 

机构地区：[1]河北医科大学附属秦皇岛第一医院肿瘤科,066000

出　　处：《中华全科医师杂志》2009年第3期185-186,共2页Chinese Journal of General Practitioners

摘　　要：1999年2月至2002年5月选择我院Ⅱ～Ⅲ期胃肠道恶性肿瘤术后患者101例，随机分为治疗组（51例）和对照组（50例），观察两组患者腹腔复发率、肝转移率及1、3、5年生存率。结果示治疗组腹腔复发率及肝转移率明显低于对照组（25．5％比50．0％，13．7％比30．0％，P〈0．05），治疗组1、3及5年的生存率明显高于对照组（P〈0．05）。提示胃肠道恶性肿瘤术后腹腔热灌注联合全身化疗，能有效降低胃肠道恶性肿瘤术后腹腔复发及肝转移，而且提高患者的生存率。A total of 101 patients undergoing operations for malignant gastrointestinal tumors （stage Ⅱ to Ⅲ） were enrolled and randomly assigned to receive intraperitoneal hyperthermal chemotherapy plus intravenous chemical injection （ treatment group, n=51 ） or routine intravenous chemical injection （ control group, n = 50）. Our results indicated that the recurrence rate and the metastatic rate in the treatment group were significantly lower than those in the control group （25.5% vs. 50. 0%, 13.7% vs. 30. 0%, both P 〈 0. 05 ）, although the 3- and 5 year-survival rates were significantly higher （ both P 〈 0.05 ）. Our data suggest that intraperitoneal hyperthermal chemotherapy plus general chemotherapy after surgery for malignant gastrointestinal tumors could effectively reduce tumor recurrence and metastases and improve long-term survival.

关 键 词：胃肠肿瘤 化学疗法 肿瘤 局部灌注 

分 类 号：R735[医药卫生—肿瘤] R735.2[医药卫生—临床医学]