文拉法辛与西酞普兰治疗抑郁症临床对照研究  

A control study on Venlafaxine and Citaloparm in the treatment of depression

作　　者：张繁新[1] 高欢[1] 

机构地区：[1]广东省深圳市康宁医院,广东深圳518020

出　　处：《中国民康医学》2009年第5期441-442,447,共3页Medical Journal of Chinese People’s Health

摘　　要：目的：评估文拉法辛与西酞普兰治疗抑郁症的疗效和不良反应。方法：将符合CCMD-3诊断标准的60例抑郁症住院和门诊患者，随机分为两组，分别予文拉法辛和西酞普兰治疗，疗程8周。用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、临床疗效总评量表的病情严重程度（CGI—S1）和不良反应量表（TESS）评定疗效和不良反应。结果：文拉法辛与西酞普兰治疗抑郁症疗效接近，但前者起效更快，不良反应少于后者。结论：文拉法辛是一种安全、有效的新一代抗抑郁药。Objective：To compare efficacy and side effects between Venlafaxine and Citaloparm in the treatment of depression. Methods ：60 inpatients and outpatients with a diagnosis of depression according to CCMD -3 were involved in this study, they were randomly assigned to the Venlafaxine group （ n = 30） and the Citaloparm group （ n = 30） for 8 weeks. Effects and side reactions were evaluated with HAMD, HAMA, CGI -SI and TESS before and after the treatment. Results： Findings indicated that efficacy of Ven- lafaxine was similar to than of Citaloparm, however, Venlafaxine took effect more quickly and its side effects were less than Citaloparm. Conclusions ： Venlafaxine is an effective and safe antidepressant. It is suggested that venlafaxine could be used as a first - line antidepressant in the treatment of depression.

关 键 词：文拉法辛 西酞普兰 抑郁症 对照研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学]