KAI-1基因在肝细胞癌中的表达与临床病理特征的关系  

Expression of KAI-1 in Hepatocellular Carcinoma and the Relationship Between the Expression and Clinical Pathological Characterization

作　　者：丘敏梅 易石坚 钟德玝[2] 杨竹林[2] 

机构地区：[1]深圳市福永人民医院外三科,广东深圳518103 [2]中南大学湘雅二医院肝胆外科

出　　处：《南华大学学报（医学版）》2008年第5期590-592,共3页Journal of Nanhua University(Medical Edition)

基　　金：深圳市科技计划项目(医疗卫生类200603187)

摘　　要：目的探讨KAI-1基因在肝细胞癌(HCC)中的表达及其与临床病理特征的关系。方法对48例HCC手术切除的新鲜标本和10例正常肝组织经常规方法应用SABC免疫组织化学法,以KAI-1单克隆抗体对切片进行染色。检测KAI-1在HCC中的表达,并分析其与临床病理特征的关系。结果KAI-1在HCC癌组织中的阳性率为58.33%,明显低于癌旁及正常肝组织(P<0.05),KAI-1在有转移与无转移HCC中的评分分别是1.76±1.51和2.90±1.82(P<0.05),而与其它临床病理特征无显著关系。结论KAI-1在HCC中的表达明显降低,且转移者明显低于不伴转移者,这表明KAI-1可能抑制了HCC的发生发展和转移。Objective To study the expression of KAI-1 in hepatocellular carcinoma and the relationship between the expression and clinical pathological characterization. Methods 48 fresh resected specimens from the patients with HCC and 10 normal liver tissue were selected,fixed with 10% formalin,paraffin embed in routine,each sample was proceeded with serial section,about 4 μm thick,tissue section of HCC were stained by SABC immunohistochemistry,with KAL-1 in HCC and the relationship between the expression and clinical pathological characterization were studied with χ^2 check,t check and Fisher precise probability. Results Positive rates of KAI-1 in the tissue was 58.33%, obviously lower than paracarcinoma tissue and normal liver tissue（P〈0.05）;the scores of KAI1 in HCC with metastatic and without metastatic cancer were 1.76±1.51 and 2.90±1.82 respectively,the scores of KAI-1 were significantly lower in HCC with metastatic than those without metastatic cancer（P〈0.05）,there were no significantly different expressions in other pathological characterization. Conclusion The expression of KAI-1 in the tissue HCC was decreased obviously,and it was lower in HCC with metastasis than those without metastasis cancer,which showed that KAI-1 possibly restrained the metastasis of HCC.

关 键 词：肝细胞癌 KAI-1基因 临床病理特征 

分 类 号：R735.7[医药卫生—肿瘤]