新辅助化疗对乳腺癌P-gp、GST-π的影响及意义  

Effects of Neoadjuvant Chemotherapy on P-gp,GST-π Expression in Breast Cancer

作　　者：杨海松[1] 黄建军[1] 

机构地区：[1]贵阳医学院附属医院乳腺外科,550004

出　　处：《肿瘤防治研究》2009年第2期147-149,共3页Cancer Research on Prevention and Treatment

基　　金：贵州省卫生厅基金项目(黔卫发[2007]119号)

摘　　要：目的探讨P-糖蛋白(P-gp)和谷胱甘肽转移酶(GST-π)在新辅助化疗乳腺癌组织的表达及临床意义。方法采用免疫组织化学方法检测100例乳癌患者新辅助化疗前后肿瘤组织中P-gp及GST-π的表达,并与疗效作相关性分析。结果新辅助化疗总有效率79%,P-gp、GST-π阳性者化疗有效率分别为69.04%和77.08%,阴性者分别为86.20%(P<0.05)和80.76%(P>0.05)。P-gp在化疗前后的阳性表达率分别为41.75%和64.83%,差异有统计学意义(P<0.05);GST-π在化疗前后阳性表达率分别为49.45%和54.94%,差异无统计学意义(P>0.05)。结论新辅助化疗后P-gp表达显著升高,P-gp对乳腺癌新辅助化疗疗效有一定预测价值。Objective To explore the expression of Pgp and GST-π in breast cancer tissue receiving neoadjuvant chemotherapy and explore its clinical significance. Methods Expressions of P-gp; GST-π in 100 breast cancer patients before and after neoadjuvant chemotherapy were measured by immunohistochemistry Envision method. The relationship between P-gp, GST-π and the effect of neoadjuvant chemotherapy was analyzed by chi-square test. Results The overall response rate to neoadjuvant chemotherapy was 79%. In patients with P-gp , GST-π positive expression, the response rate to chemotherapy were 69. 04%, and 77. 08%, and in patients with P-gp ,GST-π negative expression, the response rate to chemotherapy were 86. 20% （P〈0. 05） and 80. 76% （P〈0.05）. The positive expression of P-gp before and after chemotherapy were 41.75% and 64. 83%, respectively, and their difference was statistically significant （P〈0. 05）. The positive expression of GST-π before and after chemotherapy were 49. 45% and 54. 940%, respectively, and no difference was found between them（P〉0. 05）. Conclusion The expression of P-gp increased significantly after neoadjuvant chemotherapy. It suggested that P-gp could be used to predict the therapeutic efficacv of neoadjuvant chemotherapy.

关 键 词：乳腺癌 新辅助化疗 P—gP GST-Π 

分 类 号：R737.9[医药卫生—肿瘤]