Tiam-1蛋白表达与鼻咽癌生物学行为的关系  

Relationship between Tiam-1 expression and the biological behaviors of nasopharyngeal carcinoma

作　　者：张香梅[1] 金贺[1] 陈娟芝[1] 于丽娜[1] 李余发[1] 丁彦青[1] 

机构地区：[1]南方医科大学病理学教研室,广东广州510515

出　　处：《南方医科大学学报》2009年第1期26-28,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(30370649;30670967;30770977;30801380);广东省自然科学重点基金(5200512);广东省科技计划重大专项(2003A308401)

摘　　要：目的探讨Tiam-1蛋白与鼻咽癌生物学行为的关系。方法用免疫组化方法检测60例不同临床分期人鼻咽癌组织、20例鼻咽粘膜慢性炎症组织以及6例裸鼠人鼻咽癌转移细胞株模型标本中Tiam-1蛋白的表达。结果Tiam-1蛋白在鼻咽癌组织中的阳性表达率63.33%高于慢性炎症组36.67%(χ2=20.429,P=0.001);Tiam-1蛋白在鼻咽癌组的平均表达得分(2.9167±1.3057)高于鼻咽粘膜慢性炎组(0.7000±0.9234)(t=7.0162,P=0.0000)。Tiam-1蛋白表达在临床T分期之间没有统计学差异(F=2.36,P=0.0811),在有无淋巴结和器官转移的肿瘤组织中均有统计学意义(P=0.0001)。在具有转移特性的人源性鼻咽癌细胞株裸鼠模型肿瘤组织中Tiam-1蛋白均呈高表达。结论Tiam-1与鼻咽癌浸润转移密切相关,提示Tiam-1蛋白可能是鼻咽癌的重要促侵袭转移因子。Objective To investigate the relationship between the protein expression of T-lymphoma invasion and metastasis gene 1 （Tiara-1） and the biological behaviors ofnasopharyngeal carcinoma （NPC）. Methods Immunohistochemistry was performed to detect the expressions of Tiam-1 protein in 60 specimens of NPC tissue, 20 specimens of chronic nasopharyngitis （CN） tissue, and 6 tumor tissues from nude mice inoculated with metastatic human NPC cells. Results The positivity rate and average score for Tiam-1 expression were significantly higher in NPC tissues than in CN tissue （63.33% vs 36.67%, 2.9167± 1.3057 vs 0.7000±0.9234; X^2=-20.429, P=0.001; t=7.0162, P=0.0000, respectively）. No difference was found in Tiam-1 expression among NPC patients in different T stages （F=2.36, P=0.0811）, while the expression differed significantly between the patients with lymph node metastasis and those without metastasis, and also between patients with organ metastasis and those without （P=0.0001）. High Tiam-1 expressions were found in the tumor tissues in nude mice inoculated with metastatic NPC cells. Conclusion Tiam-lexpression is closely associated with the invasiveness and metastasis of NPC, indicating that Tiara-1 is an important factor that promotes the invasion and metastasis of NPC.

关 键 词：鼻咽癌 T淋巴瘤侵袭转移诱导因子1 生物学行为 

分 类 号：R739.63[医药卫生—肿瘤]