^(12)C^(6+)重离子束照射治疗复发性软组织肉瘤临床疗效探讨  

Recrudescent soft tissue sarcoma treated by ^(12)C^(6+) heavy ion beam radiotherapy

作　　者：魏世华[1] 李莎[1] 张红 岳养军[1] 田种泽[1] 李强 陈小华[1] 

机构地区：[1]兰州军区兰州总医院放射治疗科,甘肃兰州730050 [2]中国近代物理研究所,甘肃兰州730000

出　　处：《第四军医大学学报》2009年第5期451-453,共3页Journal of the Fourth Military Medical University

基　　金：国家"863"课题(2006AAo2z499);国家自然科学基金(10675151)

摘　　要：目的:应用我国自主研发的重离子加速器产生的12C6+重离子束治疗复发性软组织肉瘤,评价其高线性能量传递(LET)及低LET在临床应用中的优劣.方法:3例经病理证实为软组织肉瘤自愿接受重离子束照射的患者,其中2例病变位于腹部,1例在背部.所有患者均为手术复发2次以上,最多达6次,并经手术行常规放疗失败.应用80～100 mev/u重离子束对3例患者分别给予总剂量72～120 GyE/6-12 f照射,生物效应剂量(RBE)=3.结果:2例患者3 mo后病变完全消失,达临床治愈;1例缩小75%,达临床部分缓解,总有效率为100%.治疗中及治疗后照射野皮肤无破溃等放射性损伤.结论:12C6+重离子束具有治疗精度高,疗程短,对肿瘤周围正常组织损伤小等特点.特别在射线抗拒的难治性肿瘤中可达到常规放疗难以实现的疗效,具有很好的临床应用前景.AIM： To report the treatment of recrudescent soft tissue sarcomas by China-made heavy ion accelerator of the 12C6＋ heavy ion beam and to evaluate the pros and cons of high-and low- LET radiotherapy in the clinical application. METHODS： Three patients pathologically diagnosed as having soft tissue sarcoma, two in the abdomen and one in the back, voluntarily took heavy ion beam radiotherapy. All 3 cases were recurrent patients, who had had surgical and radiotherapy treatment but no good results. Each of the patients was exposed to 80-100mev/u heavy ion beam, a total dose of 72-120GYE/6-12f（ RBE = 3 ）. RESULTS ： Three months after the treatment, tumors disappeared in two of the three cases, evaluated clinically as complete recovery, and in the other one ease, the tumor reduced by 75% in size, evaluated clinically as partial recovery. The total effective rate was 100% and no radioactive damage of irradiation was observed in normal tissues during or after radiotherapy. CONCLUSION： 12C6＋ heavy ion beam has the advantage of high accuracy, short course of treatment, and slight lesion of normal tissues round sarcoma, especially in some ray-resistant refractory tumors for conventional radiotherapy.

关 键 词：肉瘤 ^12C^6+重离子 线性能量传递(LET) 放射治疗 

分 类 号：R730.55[医药卫生—肿瘤]