Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice  

作　　者：Cuiqing Ma Caihong Li Xiurong Wang Ruihong Zeng Xiaolin Yin Huidong Feng Lin Wei 

机构地区：[1]Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China

出　　处：《Cellular & Molecular Immunology》2009年第1期73-77,共5页中国免疫学杂志（英文版）

基　　金：supported by National Natural Science Foundation of China (30771970 and 30872399);Scientific Research Foundation of Health Bureau of Hebei Province (08054).

摘　　要：Group A streptococcus （GAS）, an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA （an Fn-binding protein expressed on the surface of GAS） with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular ＆ Molecular Immunology.Group A streptococcus （GAS）, an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA （an Fn-binding protein expressed on the surface of GAS） with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular ＆ Molecular Immunology.

关 键 词：group A streptococcus IMMUNOGENICITY FbaA M protein IMMUNOPROTECTION 

分 类 号：R378.12[医药卫生—病原生物学] R733.3[医药卫生—基础医学]