胃癌高发区幽门螺杆菌感染与胃黏膜肠化生关系的研究  

The relationship between intestinal metaplasia gastric mucosa and Helicobacter pylori infection in the high risle area of gastric cancer

作　　者：惠起源[1] 魏晓萍[1] 冯义朝[1] 崔轶霞[1] 党冬梅[1] 

机构地区：[1]延安大学医学院病理教研室,陕西延安716000

出　　处：《现代肿瘤医学》2009年第3期494-495,共2页Journal of Modern Oncology

基　　金：陕西省教育厅自然科学专项基金(05JK316)

摘　　要：目的:探讨陕北胃癌高发区幽门螺杆菌(HP)感染与胃黏膜肠化生之间的关系。方法:收集两次普查中行胃镜检查的病例共487例,把慢性胃炎病例(479例)分为无肠化生及轻、中、重度肠化生4组,检测、比较各组之间HP的感染率。结果:无肠化生及轻、中、重度肠化生组HP感染率分别为55.87%、80.52%、76.56%、67.74%。轻、中度肠化生组HP感染率明显高于无肠化生组(P值均<0.05)。其余各组之间HP感染率比较无显著性差异(P值均>0.05)。结论:陕北胃癌高发区轻、中度肠化生与HP感染密切相关。Objective：To study the relationship between the intestinal metaplasia gastric mucosa and Helicobacter pylori infection in the high incidence area of gastric cancer.Methods： All 487 cases were collected in two census,among them 479 chronic gastritis cases with negative,lightly,middle and heavy intestinal metaplasia were tested for Helicobacter pylori infection.Results： The infection rate of HP in negotive,lightly,middle and heavy intestinal metaplasia groups were 55.87%,80.52%,76.56% and 67.74% respectively.The infection rates of HP infection in lightly and middle were much higher than the negative intestinal metaplasia group（P〈0.005）.There was no difference among other groups（P〉0.05）.Conclusion： Helicobacter pylori infection is related with lightly and middle intestinal metaplasia in the high incidence area of gastric cancer.

关 键 词：胃癌高发区 幽门螺杆菌 感染 肠化生 

分 类 号：R735.2[医药卫生—肿瘤]