奥沙利铂/氟尿嘧啶改良时辰化疗治疗晚期结直肠癌  

Clinical research of modified chronochemotherapy of oxaliplatin/5-FU/leucovorin for advanced colorectal cancer

作　　者：陈昕[1] 杨健[2] 龚光[2] 袁泉[2] 邓红梅[3] 贾钰铭[1] 

机构地区：[1]四川省宜宾市第二人民医院肿瘤科,四川宜宾644000 [2]四川省宜宾市第二人民医院普外科,四川宜宾644000 [3]四川省宜宾市第二人民医院五官科,四川宜宾644000

出　　处：《现代肿瘤医学》2009年第3期517-518,共2页Journal of Modern Oncology

摘　　要：观察奥沙利铂/氟尿嘧啶/亚叶酸钙时辰化疗治疗晚期结直肠癌的临床疗效。96例晚期结肠癌患者随机分为时辰化疗和常规化疗组。时辰化疗组46例,采用持续静脉滴注,并按时辰调节给药速度;常规化疗组44例,常规静脉给药。时辰化疗组有效率45.7%;常规化疗组有效率25.0%。奥沙利铂联合CF/5-FU双周方案采用时辰给药方式,可提高疗效,减轻化疗不良反应。To observe the effect of chronochemotherapy of oxaliplatin/5-FU/leucovorin for advanced colorectal cancer.Ninety advanced colorectal cancer patients were randomly divided into chronochemotherapy group and control group.In chronochemotherapy group 46 patients received oxaliplatin and 5-FU by chronomodulation,the continually IV speed was regulated by time.In control group 44 patients received oxaliplatin regularly.In chronochemotherapy group the response rate was 45.7%,in control group the response rate was 25.0%.The effect of chronochemotherapy group was significantly better than control group.Chronochemotherapy of oxaliplatin/5-FU/leucovorin is eflective for advanced colorectal cancer.

关 键 词：时辰化疗 晚期结直肠癌 生物节律 奥沙利铂 5-FU 

分 类 号：R735.34[医药卫生—肿瘤]