脑卒中SELP基因C-2123G多态性研究  

The relationship of P-selection C-2123G gene polymorphism with stroke

作　　者：谷文萍[1] 王妮妮[1] 唐春柳[1] 宋小明[1] 李伟[1] 梁静[1] 杨期东[1] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙410008

出　　处：《中风与神经疾病杂志》2009年第1期41-43,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金资助项目(No.3060199);教外司留学回国基金(教外司留[2006]331号)

摘　　要：目的探讨P-选择素C-2123G基因多态性与中国湖南地区汉族人群脑卒中的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测311例脑卒中患者和174例健康对照者P-选择素C-2123G基因多态性。结果中国湖南地区汉族人群P-选择素基因C-2123G多态存在GG、CG、CC 3种基因型,脑卒中组多态基因频率与对照组相比无显著性差异(P>0.05)。结论P-选择素基因C-2123G多态性可能不是中国湖南地区汉族人群脑卒中的遗传易感基因。Objective To explore the relationship of SELP C-2123G gene polymorphism with atherosclerotic cerebral infarction（ACI） and intracerebral hemorrhage （ICH）in Han population in Hunan province. Methods Polymerase Chain Reaction-Restriction Fragment Length Polymorphism（PCR-RFLP） was performed to identify the distributions of allele and genotype frequencies of SNP C-2123G polymorphism of P-selection gene in 311 patients with stroke and 174 healthy con- trois. Results SELP C-2123G gene polymorphism revealed no significant difference between GG,CG and CC genotype and G and C allelic distribution in stroke patients and controls. （P 〉 0.05）. Conclusion There is no relationship between the SELP C-2123G gene polymorphism and stoke in Han population in Hunan province.

关 键 词：P-选择素 脑卒中 多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]