钾通道与乳腺癌细胞的增殖和转移(英文)  

Potassium channels and proliferation and migration of breast cancer cells

作　　者：张磊[1] 邹伟[1] 周士胜[2] 陈冬冬[1] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]大连大学医学院,大连116600

出　　处：《生理学报》2009年第1期15-20,共6页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China (No. 30570225);the Education Department of Liaoning Province (No. 05L206)

摘　　要：K+通道是细胞膜上一类特殊的蛋白质离子孔道,参与细胞内多种重要的生理活动的调节。近年来发现,K+通道不仅与神经系统、心血管系统疾病相关,而且可以作为治疗通道疾病的靶点。许多研究表明,K+通道基因在乳腺癌和其它肿瘤形成过程中还具有原癌基因特性,其编码的蛋白决定着细胞的增殖、癌变、侵袭和转移。本文概括介绍了K+通道与乳腺癌的发生、肿瘤细胞增殖和转移等方面的研究进展。Potassium channels （K^＋ channels）, a family of special ion channel proteins, are involved in various physiological functions. Recent data show that the abnormalities of K^＋ channels are not only responsible for some neurological and cardiovascular diseases but also for channelopathies. Furthermore, many groups reported that the abnormalities of K^＋ channels had shown their oncogenic potential in breast introduction and other malignant tumors, promoting proliferation, invasion and metastasis. The aim of this review is to give an updated introduction of research progress in K^＋ channels associated with breast cancer.

关 键 词：K^+通道 乳腺癌 增殖 转移 

分 类 号：R737.9[医药卫生—肿瘤]