151例食管小细胞癌的治疗与预后分析  

Treatment and prognosis of primary esophageal small cell carcinoma:a report of 151 cases

作　　者：宋岩[1] 王绿化[2] 赫捷[3] 王金万[1] 

机构地区：[1]中国医学科学院肿瘤医院内科,北京100021 [2]中国医学科学院肿瘤医院放射治疗科,北京100021 [3]中国医学科学院肿瘤医院胸外科,北京100021

出　　处：《癌症》2009年第3期303-307,共5页Chinese Journal of Cancer

摘　　要：背景与目的:原发性食管小细胞癌是一种少见的食管恶性肿瘤,有关其治疗及预后的文献报道不多。本研究旨在分析原发食管小细胞癌的临床特点、治疗方法和预后。方法:回顾性分析1982年4月至2007年7月中国医学科学院肿瘤医院收治的151例食管小细胞癌患者的临床资料,根据VALSG标准分期,其中局限期138例,广泛期13例。数据分析采用SPSS13.0统计软件,生存分析应用Kaplan-Meier法,生存率比较采用log-rank方法检验。结果:151例患者的6、12、24、36和60个月生存率分别为86.6%、56.7%、24.8%、17.4%和12.0%。多因素分析显示临床分期和脉管瘤栓是影响预后的独立因素。局限期患者中接受以化疗为基础的综合治疗者中位生存期12.3个月,与局部治疗者的7.7个月比较差异有统计学意义(P<0.05)。结论:食管小细胞癌易早期转移,预后不佳,以化疗为基础的综合治疗有助于延长其短期生存期。Background and Objective： The treatment and prognosis of primary esophageal small cell carcinoma （PESC）, an uncommon esophageal malignant tumor, have seldom been reported. This study was to analyze the clinical characteristics, treatment and prognosis of PESC. Methods： Clinical data of 151 patients treated in Cancer Hospital, Chinese Academy of Medical Sciences, from 1982 to 2007 were reviewed. The median age of the patients was 59 years. According to VALSG criteria, 138 patients had limited disease （LD）, 13 had extensive disease （ED）. Patients received surgery, chemotherapy and/or radiotherapy. The survival rate was calculated by the Kaplan-Meier method and the log-rank test using SPSS 13.0 software. Results.The 6-, 12-, 24-, 36- and 60-month survival rates of these patients were 86.6%, 56.7%, 24.8%, 17.4% and 12.0% respectively. The clinical stage and vessel involvement were independent prognostic factors of PESC. The median survival time was longer in LD patients （12.3 months） than in those underwent local treatment alone （surgery or radiotherapy）, Conclusions： PESC is a malignant tumor with early metastasis and poor prognosis. Combined therapy based on chemotherapy may improve the short term survival of PESC patients.

关 键 词：食管肿瘤 小细胞癌 综合治疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]