柯萨奇-腺病毒受体在肿瘤发生发展机制中的研究进展  

Research advance on role of Coxsackie and adenovirus receptor(CAR) in tumor progression

作　　者：范良生[1] 陈刚[1] 马丁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030

出　　处：《癌症》2009年第3期333-336,共4页Chinese Journal of Cancer

基　　金：国家自然科学基金项目资助(No.30700895)~~

摘　　要：柯萨奇-腺病毒受体(Coxsackie and adenovirus receptor,CAR)最早作为2型和5型腺病毒的受体而被人们发现和认识。大量研究发现CAR可以影响肿瘤细胞的生长、细胞骨架的变化、细胞间的粘附等,从而在肿瘤侵袭转移过程中起非常重要的作用。而且,CAR的表达与肿瘤的预后和腺病毒介导的减瘤效应也有密切的关系。基于CAR的重要作用,CAR已逐渐成为肿瘤发生发展机制及治疗领域研究中新的"热点",本文结合CAR的基本结构及功能对以上研究的进展作一综述。Coxsackie and adenovirus receptor （CAR） is originally identified as the cellular receptor of 2- and 5-type adenoviruses. Many researches have suggested that CAR can affect the growth, adhesive ability and cytoskeleton of tumor cells, and has complicated functions in metastasis and invasion of tumors. Moreover, the expression of CAR has close relationship with tumor prognosis and cytoreduction mediated by adenoviruses. CAR has become a new hotspot in the research on mechanism of tumor progression and gene therapy. Our review focuses on the structure and function of CAR and its role in mediating occurrance and progression of tumor.

关 键 词：柯萨奇-腺病毒受体 肿瘤 病因学 减瘤作用 预后 

分 类 号：R730.2[医药卫生—肿瘤]