Rho GTPase在信号转导和细胞骨架中的作用  

Roles of Rho GTPase in signaling transduction and cytoskeleton

作　　者：姚志红[1] 唐圣松[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《国际病理科学与临床杂志》2009年第1期20-26,共7页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30270684);湖南省自然科学基金重点项目(08JJ5004)~~

摘　　要：Rho GTPases参与多种重要的细胞生命活动,如肌动蛋白细胞骨架的重构、细胞黏附、细胞运动、囊泡运输、转录激活、基因表达和细胞周期的调控等。当Rho GTPase蛋白水平改变,活性状态改变,效应蛋白丰度改变后,出现异常的Rho信号,从而影响细胞骨架重组使细胞迁移。调节这些生物信号的转导通路非常复杂,因此,Rho GTPases已成为近年来的研究热点。Rho GTPases control many features of cell behavior. They play a pivotal role in regulating actin cytoskeletal organization, cell adhesive interactions, cell migration, vesicle trafficking, transcriptional activity, gene expression and cell cycle progression. Aberrant Rho signaling is resulted from alterations in the levels of Rho GTPase proteins, the status of activation, and the abundance of effector proteins. Alterations of Rho signaling particularly impact on the cytoskeleton reorganization to underpin the motility of cells. Regulation of the biological signaling pathway is complex and therefore, Rho GTPases in recent years have became the hotspot.

关 键 词：RHO GTPASES 信号转导 细胞骨架 

分 类 号：Q2[生物学—细胞生物学]