云南高校图书馆联盟文献共享服务平台- GTPASES

GTPASES: 作品数：47被引量：124H指数：5; 导出分析报告; 相关作者：李岩毕锋赵丽吕媛媛龚丽景更多>>; 相关机构：北京体育大学复旦大学南方医科大学苏州大学更多>>; 相关期刊：《生命科学研究》《Cellular & Molecular Immunology》《Frontiers in Biology》《Chinese Journal of Natural Medicines》更多>>; 相关基金：国家自然科学基金教育部“新世纪优秀人才支持计划”国家重点基础研究发展计划江苏省自然科学基金更多>>

ROPs:植物细胞内多种信号通路的分子开关被引量：5: 《中国生物化学与分子生物学报》2022年第3期271-283,共13页廖恒毅王若霖黄进; 国家自然科学基金项目(No.31870383)资助。; 植物RHO相关蛋白GTPases(RHO-related GTPases of plants,ROPs)是广泛存在于植物中的一类信号转导G蛋白(又称GTP结合蛋白),其通过结合GDP或GTP在非活性和活性状态间进行切换,进而在细胞极性控制、形态发育、激素水平调控、逆境反应等诸...; 关键词：植物RHO相关蛋白GTPases(ROPs) 极性生长植物激素胁迫反应

Sensors for the mTORC1 pathway regulated by amino acids: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2019年第9期699-712,共14页Xiu-zhi LI Xiang-hua YAN; National Natural Science Foundation of China(Nos.31520103915,31730090,and 31322053);the Hubei Provincial Natural Science Foundation of China(No.2018CFA020); The mechanistic target of rapamycin complex 1(mTORC1)controls cell growth and metabolism in response to various environmental inputs,especially amino acids.In fact,the activity of mTORC1 is highly sensitive to changes...; 关键词：Mechanistic target of rapamycin complex 1(mTORC1) Amino acid Sensor LYSOSOME Rag GTPases

From basic researches to new achievements in therapeutic strategies of KRAS-driven cancers被引量：2: 《Cancer Biology & Medicine》2019年第3期435-461,共27页Mahsa Saliani Razieh Jalal Mohammad Reza Ahmadian; supported by the European Network on Noonan Syndrome and Related Disorders (NSEuroNet, Grant No.01GM1602B);the German Federal Ministry of Education and Research(BMBF): German Network of RASopathy Research (GeNeRARe, Grant No.01GM1519D & 01GM1902C); Among the numerous oncogenes involved in human cancers, KRAS represents the most studied and best characterized cancerrelated genes.Several therapeutic strategies targeting oncogenic KRAS(KRASonc) signaling pathways h...; 关键词：Direct inhibition DOWNSTREAM EFFECTORS oncogenic KRAS drug target sites small GTPASES signal TRANSDUCTION targeting synthetic lethal interactions therapeutic strategies

RhoU基因沉默对破骨细胞分化的影响被引量：1: 《畜牧兽医学报》2019年第9期1706-1713,共8页郑嘉铭贺双江赵鸿雁宋瑞龙刘宗平; 国家重点研发计划支持项目(2016YFD0501208);国家自然科学基金(31672620;31702304;31872533);江苏省自然科学基金青年基金项目(BK20150447);江苏高校优势学科建设工程资助项目; 为了研究RhoU(Wrch1)在破骨细胞(osteoclast,OC)分化过程中的作用及其机理,试验以RAW 264.7细胞(单核巨噬细胞系)为基础材料,分别转染阴性慢病毒和siRhoU慢病毒并建立稳定的细胞系;在巨噬细胞集落刺激因子(M-CSF)和核因子κB受体活化因...; 关键词：RhoU RAW 264.7细胞破骨细胞 RHO GTPASES 细胞骨架

Rac GTPases:domain-specific functions in neuronal development被引量：1: 《Neural Regeneration Research》2019年第8期1367-1368,共2页Steffen Norgaard Roger Pocock; supported by a grant from an NHMRC Project Grant(GNT1105374);NHMRC Senior Research Fellowship(GNT1137645);a Victorian Endowment for Science,Knowledge and Innovation Fellowship(VIF23)(to RP); Understanding fundamental mechanisms governing axon outgrowth and guidance can inform the development of therapeutic strategies to restore neuronal function damaged though injury or disease. Axons navigate the extrace...; 关键词：RAC GTPASES domain-specific FUNCTIONS NEURONAL DEVELOPMENT

YAP在肝癌细胞HepG2迁移中的作用及其分子机制: 《医用生物力学》2019年第A01期166-166,共1页苏冠月冯唐何佳高文博马伦杰沈阳刘肖珩; 国家自然科学基金项目(31670960); 目的肝癌是一种严重危害人类健康的恶性疾病,由于肝癌细胞极易发生迁移、侵袭和转移,导致其治疗效果不佳,且极易术后复发。YAP是机体内重要的转录共激活因子,与肿瘤的发生发展密切相关,有望成为肝瘤治疗新靶点。本研究的目的是探讨YAP...; 关键词：肝细胞肝癌迁移侵袭 YAP RHO GTPASES

Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons被引量：2: 《Journal of Genetics and Genomics》2019年第2期87-96,共10页Tao Tao Jie Sun Yajing Peng Pei Wang Xin Chen Wei Zhao Yeqiong Li Lisha Wei Wei Wang Yanyan Zheng Ye Wang Xuena Zhang Min-Sheng Zhu; supported by grants from the National Natural Science Foundation of China (31272311 and 31330034) to M.S.Z.; As a critical guanine nucleotide exchange factor(GEF) regulating neurite outgrowth, Trio coordinates multiple processes of cytoskeletal dynamics through activating Rac1, Cdc42 and RhoA small GTPases by two GEF domains...; 关键词：TRIO GEF Rho GTPASES AXON OUTGROWTH CEREBELLAR granule neuron

艰难梭菌毒素A对K562细胞Rho GTPases及细胞骨架的影响被引量：1: 《中国实验血液学杂志》2018年第5期1330-1335,共6页赵龙陈彻李明张豪刘蓓傅思武席亚明; 2014年兰州市科技计划项目(2014-1-37),2015年兰州大学第一医院院内基金(ldyyyn2015-09)。; 目的:研究艰难梭菌毒素A(TcdA)对白血病K562细胞株Rho GTPase及细胞骨架的影响。方法:体外培养K562细胞经不同浓度的TcdA处理,采用四唑蓝比色试验(MTT)检测TcdA对K562细胞增殖的影响;RT-PCR法检测TcdA作用后细胞骨架调节蛋白相关基因cd...; 关键词：艰难梭菌毒素A K562细胞 RHO GTPASES RAC1 细胞骨架

Signal integration in the （m）TORC1 growth pathway: 《Frontiers in Biology》2018年第4期237-262,共26页Kailash Ramlaul Christopher H. S. Aylett; BACKGROUND： The protein kinase Target Of Rapamycin （TOR） is a nexus for the regulation of eukaryotic cell growth. TOR assembles into one of two distinct signalling complexes, TOR complex 1 （TORC1） and TORC2 （mTO...; 关键词：mTORC 1 nutrient sensing GATOR complex TSC complex Rag GTPases RHEB

Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements被引量：1: 《Journal of Genetics and Genomics》2018年第6期299-313,共15页Hongmei Ke Zhi Feng Min Liu Tianhui Sun Jianli Dai Mengqi Ma Lu-Ping Liu Jian-Quan Ni Jos Carlos Pastor-Pareja; funded by grants from the Natural Science Foundation of China (Nos.31771600 and 31750410689);Tsinghua Initiative Program (No.20131089281);a 1000 Talents award,all to J.C.P.-P; Collagens are large secreted trimeric proteins making up most of the animal extracellular matrix.Secretion of collagen has been a focus of interest for cell biologists in recent years because collagen trimers are too ...; 关键词：Collagen Ⅳ COPⅡ vesicles RNAi screening Secretory pathway Rab-GTPases ER exit site

GTPASES