A new study from Feng et al.developed an improved proximity labeling technology called PhastID and successfully identified the lysosomal v-ATPase subunit ATP6AP1 as an unconventional guanine nucleotide exchange factor...
the National Natural Science Foundation of China(31930058 and 32330023 to Z.S,32070778 to S.W.,81871111 and 32071433 to F.L,32300562 to Z.Z.);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020044 to F.L.,2019A1515011552 to S.W.,2022A1515111054 to Z.Z.).
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1(mTORC1)to coordinate signaling cascades in response to nutrients and growth factors.Despite extensive s...