supported by grants from the STI2030-Major Projects(2021ZD0204000);the Key Strategic Science and Technology Cooperation Project(2023YFE0206800);the Ministry of Science and Technology of China,the National Natural Science Foundation of China(31820103005,32170976,32100791,and 81971874),Zhejiang Province Natural Science Foundation of China(LZ24C090003 and LY21C090003);the Peak Discipline Cultivation Program of Zhejiang University School of Basic Medicine.
Dear Editor,In recent years,there has been an increasing focus on the non-motor functions of the cerebellum[1,2].Clinical observations have demonstrated that individuals with cerebellar damage exhibit affective insens...
Military Medical Advancement Program for Air Force Medical University(2020SWAQ04);Shaanxi Innovation Ability Support Plan(2023-CX-PT-33);Shaanxi Province Natural Science Basic Research Program(2024JC-ZDXM-60,2022JQ-820);New Clinical Technology of Xijing Hospital(2023XJSY27);National Natural Science Foundation of China(82201627)。
Objective To investigate the distribution of mitochondria-associated molecule mRNA in cerebellar Purkinje cells.Methods Transgenic technology was used to prepare Pcp2-tdTomato mouse labeled Purkinje cells.The mRNAs of...
Cholesteatoma is a fairly otologic common problem. However, cholesteatoma invading the internal auditory canal (IAC) is rare and typically results in profound hearing loss and facial paralysis. This is a case of a 46-...
Beijing Municipal Committee of Science and Technology(Z201100005620010);Chinese Academy of Medical Sciences clinical and translational medicine(2022-I2M C&T-B 116);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M 5-029);Ministry of Finance of the People’s Republic of China(issued by Finance and Social Security(2015)Document No.82;(2016)Document No.50;(2017)Document No.72;(2018)Document No.48;(2019)Document No.77;(2020)Document No.75;(2021)Document No.84,Ministry of Finance and the National Key R&D Program of China(2022ZD0118005).
Background and purpose Acute vestibular syndrome(AVS)typically manifests as isolated dizziness or vertigo with no apparent neurological impairments.However,distinguishing life-threatening stroke from innocuous periphe...
Supported by National Natural Science Foundation of China,No.81573807。
BACKGROUND Cerebral small vessel disease(CSVD)is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease.A clear understanding of the underlying causes of CSVD rema...
supported by grants from the National Natural Science Foundation of China to WL(Nos.32220103006,and 82271524);the Liaoning Provincial Natural Science Foundation Joint Fund toTL(No.2023-MSLH-029);Shanghai Pudong New Area Health Commission Clinical Characteristic Discipline Construction Plan to TL(No.PWYts2021-02).
Parkinson's disease(PD)is a neurodegenerative disease characterized by various motor and non-motor symptoms.The com-plexity of its symptoms suggests that PD is a heterogeneous neurological disorder Its pathological ch...
supported by the National Natural Science Foundation of China to Zhiying Wu(Nos.82071260,82230062).
To the Editor:Spinocerebellar ataxia type 3(SCA3)is the predominant subtype,representing 48-73%of all SCAs in the Chinese population.[1]It primarily manifests as progressive ataxia,characterized by unsteady gait,dysar...
Supported by The Sichuan Medical Youth Innovation Research Project,No.Q22044.
BACKGROUND An ependymoma is a glial tumor that usually occurs in or near the ventricle,close to the ependyma.It rarely occurs exclusively in the brain parenchyma without being associated with the ventricle.CASE SUMMAR...
This case reports a presentation of multiple cerebellar infarcts.The 42-year-old male patient presented to the emergency department with a 3-day history of dizziness accompanied by speech abnormalities,visual rotation...
BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor aggressiveness.However,its pathogenesis remains unclear.Genetic test...