慢性胃病与胃粘膜细胞保护因子的相关性研究  

The Relationship Between Chronic Stomach Diseases and Cytoprotective Agents of Gastric Mucosa

作　　者：翟兴红[1] 赵荣莱[1] 赵子厚[1] 王立[2] 张锁雅[1] 梁代英[1] 李春森 

机构地区：[1]北京市中医研究所,北京100010 [2]北京中医医院消化科,北京100010

出　　处：《中国中西医结合脾胃杂志》1998年第1期9-11,共3页

基　　金：北京市自然科学基金!2932009

摘　　要：通过检测慢性胃病时胃粘膜病变与非蛋白流基物质（NPSH）、谷胱甘肽过氧化物酶（GSH－px）、过氧化氢酶（CAT）含量水平的变化，研究慢性胃病时胃粘膜损伤的有关机制。结果表明，GSH－px与慢性胃粘膜病变程度有一定的负相关性，轻度CSG组和中重度CSG组GSH－px分别为（35．12±3．06）U／mg和（34．52±2．00）U／mg．GU组则降低为（20．99±363）U／mg，与前二组比较P＜0．05、中医脾胃湿热证NPSH及GSH－px水平在各脾胃证型组中最低，分别为（0．01±0.01）μg／mg及（17.45±4.80）U／mg。结果提示，脾胃湿热时冒粘膜损伤较为明显，脾虚时胃粘膜防御能力有所减弱。The relationship between chronic stomach diseases and the endogenous substanceswith cytoprotective effects such as NPSH , CAT was studied. The results indicated that GSH-pxactivity in gastric mucosa was negatively related with the degree of chronic mucosal damage. Theenzyme activity in mild and severe CSG groups was (35. 12 ± 3. 06 ) and (34. 52 ± 2. 00 ) U/mgpro, but the activity in CSG group (P< (0.05), The lowest level of NPSH and GSH-px suggested the gastric mucosa had markedly been injured in patients with gastric-spleen damp and heat,and the defensive ability of mucosa tended to decrease in patients with spleen deficiency.0

关 键 词：胃疾病 胃粘膜损伤 非蛋白巯基 GSH-PX 

分 类 号：R573.02[医药卫生—消化系统]