抑郁症患者血清S100B蛋白浓度变化  

Increased Serum S100B Protein in Patients with Major Depression

作　　者：过斌[1] 谭云龙[1] 杨甫德[1] 邹义壮[1] 张向阳[1] 曹连元[1] 张五芳[2] 周宇[1] 郑丽丽[1] 周东丰[2] 

机构地区：[1]北京回龙观医院,北京100096 [2]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191

出　　处：《中国心理卫生杂志》2009年第3期188-191,共4页Chinese Mental Health Journal

基　　金：北京市优秀人才培养基金(20061D0301400098)

摘　　要：目的:探讨首发和复发抑郁症患者血清S100B蛋白浓度的改变。方法:采用酶联免疫(ELISA)方法检测61例抑郁症患者(抑郁症组,其中首发19例,非首发42例)和52名健康对照(对照组)血清S100B蛋白浓度,比较两组间血清S100B蛋白浓度的差异;采用汉密尔顿抑郁量表(HAMD)评定抑郁症患者的抑郁症状,分析血清S100B蛋白浓度与HAMD评分及疾病状况间的关系。结果:(1)抑郁症组血清S100B浓度高于对照组[(0.17±0.10)vs.(0.11±0.04)μg/L](P<0.001);(2)抑郁症组首发和非首发患者间血清S100B浓度差异无统计学意义[(0.15±0.04)vs.(0.17±0.12)μg/L,P=0.430];(3)抑郁症组血清S100B浓度与患者年龄、总病程、HAMD评分无相关(P>0.05),与患者首发时年龄、发病次数相关(r=-0.29,0.36;P=0.024,0.005)。结论:抑郁症患者血清S100B浓度高于正常对照,尽管与疾病症状无关,但可能在一定程度上反映疾病复发可能性的生物学指标。Objective： To investigate the relationship of serum S100B protein levels with traits of major depression. Methods： The serum SI00B protein levels in 61 major depression patients （depression group, including 19 cases of first-episode, 42 cases of recurrence ） and 52 healthy volunteers （ control group ） were examined by enzyme- linked immuno-sorbent assay （ ELSIA） . The serum SIOOB levels were compared between the patients with major depression and controls. Depression symptoms were assessed with the Hamilton Depression Rating Scale （ HAMD ）, and the relationships between serum S100B levels and traits of the disorder were analyzed in depression group. Results： （ 1 ） The serum S100B level in depression group was significantly higher than that in control group [ （0. 17±0. 10） vs. （ 0. 11 ± 0. 04） μg/L; P 〈 0. 001 ] . （ 2 ） There were no significant differences between first-episode and recurring sub-groups in depression group [ （0. 15 ±0.04） vs. （0. 17 ±0. 12） μg/L; P=0.430] . （3） Serum S100B level was significantly correlated with age of first-episode （ r = - 0. 29, P = 0. 024 ） and onset times （ r = 0. 36, P = 0. 005 ） in depression group. Conclusion： The serum S100B protein levels in patients with major depression are higher than that in normal control. Serum S100B protein may be a prognosis-related biomarker for major depression.

关 键 词：抑郁症 S100B蛋白 血清 病例对照研究 

分 类 号：R749.41[医药卫生—神经病学与精神病学]