高海拔地区牙源性疾病厌氧菌的药物敏感性试验  

DRUG SENSITIVITY TEST OF ANAEROBIC BACTERIA IN ODONTOGENIC DISEASE AT HIGH ALTITUDE

作　　者：陆东明[1] 邵嘉会[1] 谢新民[2] 

机构地区：[1]青海医学院微生物教研室,810001 [2]青海医学院生理学教研室,810001

出　　处：《高原医学杂志》1998年第1期25-27,共3页Journal of High Altitude Medicine

摘　　要：目的：为了解高海拔地区口腔疾病的专性厌氧菌对常用抗生素的敏感性，并为选择用药提供依据;方法：采用9种药物对西宁地区（2260m）分离的64株口腔牙源性疾病常见厌氧菌与国际代表菌株进行体外药物敏感性试验。并对拟杆菌属中产黑色素与不产黑色素拟杆菌进行药敏试验对比观察;结果：对厌氧菌似杆菌效果较好的药物分别为甲硝唑、利福平、头孢唑啉（高度敏感菌株数分别为79.69％，78.13％，25.00％）。产黑色素拟杆菌有效药物敏感性与不产黑色素拟杆菌略一致;结论：从牙源性疾病中分离的64株厌氧菌中，专性厌氧菌比例高于平原，提示了高海拔地区临床用药应合用抗厌氧菌抗生素。To examine the susceptibilities of antibiotics to anaerobic bacteria in odontogenic disease at high altitude. Methods:Drug susceptibility of 64 strains of anaerobic bacteria in odontogenic desaese and interna nonal standard strains were tested with 9 kinds of drugs in vitro in Xining. And the drug sensitivity test of bacteroides melaninogenicus was taken and compared with non-melaninogenicus. Results: Metronidazole, Rifarnpin and Chloramphenicol were more effects.The high sensitive strains to the three drugs expressed to 79.79%, 78.13% and 25.0% separately. No difference between melaninogenicus and non-melaninogenicus. Conclusion: The obligat anaerobe in 64 strains in odontogenic disease is higher at high altitiude than that in sea level. The results suggest that it is better to taka antibiotics-antianaerobe with clinical therapy at high altitude.

关 键 词：厌氧菌 牙源性疾病 药敏试验 

分 类 号：R780.2[医药卫生—口腔医学]