血清Ang-2及VEGF水平与子宫肌瘤的相关性研究  

Correlation of serum angiopoietin-2,vascular endothelial growth factor and uterine leiomyoma

作　　者：高英芳[1] 刘素巧[2] 方芳[1] 赵淑荣[1] 陈利社[1] 刘朝霞[1] 

机构地区：[1]河北省石家庄市第四医院,050011 [2]河北省石家庄市第二医院

出　　处：《河北医药》2009年第4期402-403,共2页Hebei Medical Journal

基　　金：河北省科技厅攻关项目(编号:07276143)

摘　　要：目的研究子宫肌瘤患者血清血管生成素-2(Ang-2)和血管内皮生长因子(VEGF)水平及与子宫肌瘤的相关性,以及作为子宫肌瘤临床检测指标的可行性。方法分别选取40例手术治疗的子宫肌瘤患者和同龄正常女性作为研究组和对照组。用ELISA法测定2组血清Ang-2、VEGF含量。结果研究组Ang-2和VEGF含量明显高于对照组,差异具有统计学意义(P<0.01)。子宫肌瘤患者Ang-2和VEGF无月经周期变化(P>0.05),Ang-2和VEGF与子宫肌瘤数无关(P>0.05)。结论Ang-2和VEGF与子宫肌瘤发病相关,Ang-2和VEGF可以作为子宫肌瘤临床检测指标之一。Objective To investigate the correlation of the levels of serum angiopoietin-2（Ang-2） as well as vascular endothelial growth factor（VEGF） and the uterine leiomyoma, to clarify the possibility of both factors as clinic examination indexes of uterine leiomyoma. Methods 40 patients with uterine leiomyoma who were treated by surgery were selected as trial group, and healthy women were selected as control group. The levels of Ang-2 and VEGF in both groups were detected by ELISA method. Results The levels of Ang-2 and VEGF in trial group were significantly higher than those of control group（ P 〈 0.01）. The levels of ang-2 and VEGF of patients with uterine leiomyoma were not changed with menstrual cycle. The levels of Ang-2 and VEGF were not correlated with numbers of uterine leiomyoma （ P 〉0.05）.Condusion Ang-2 and VEGF are correlated with the pathogenesis of uterine leiomyoma, and ang-2 and VEGF can be used as clinic examination indexes.

关 键 词：子宫肌瘤 血清血管生成素-2(sAng-2) 血管内皮生长因子(sVEGF) 

分 类 号：R737.33[医药卫生—肿瘤]