不同稀释A型肉毒毒素的方法对脑卒中后上肢痉挛疗效的观察  

Botulinum toxin type A in upper limb spasticity after stroke:a clinical trial comparing dilution techniques,CUI

作　　者：崔利华[1] 张通[1] 杨凌宇[1] 

机构地区：[1]首都医科大学神经病学系北京博爱医院神经康复科,北京100068

出　　处：《中国当代医药》2009年第5期130-131,共2页China Modern Medicine

摘　　要：目的:本研究主要是探讨不同稀释A型肉毒毒素的方法在治疗脑卒中后上肢痉挛的疗效对比分析。方法:将19例脑卒中患者随机分为两组,均采取在肱二头肌注射100 U的药品,注射4个位点。A组:11例,肉毒毒素被稀释为50 U/ml的溶液,共2 ml;B组:8例,肉毒毒素被稀释为25 U/ml的溶液,共4 ml。分别于治疗前及治疗后2、4、8周用改良的Ashworth评分(MAS)评定肌张力。结果:两组患者治疗前及治疗后2、4、8周MAS评分降低程度无统计学意义(P>0.05)。结论:在相同剂量的情况下,CBTX-A稀释成50 U/ml组和稀释成25 U/ml组在降低肌痉挛的疗效方面没有明显差异。Objective：This study was carried out to compare the effective of the different dilution techniques of intramus cular injection China botulinum toxin A （CBTX-A）. Methods： 19 post-stroke patients ,who received 100 U CBTX-A intramuscular injection on biceps, were randomly derided into 2 groups： Group A （n=l 1）, with 50 U/ml of CBTX-A dilution; Group B （n=8）, with 25 U/ml of CBTX-A dilution. The Modified Ashworth Scale was assessed at the baseline, 2-week, 4-week and 8-week after treatment. Results：There was no significant between two groups at pre-injection and 2,4,8-week post-injection （P〉0.05）. Conclusion：There was no significant between group with 50 U/ml of CBTX-A dilution and group with 25 U/ml of CBTX-A dilution, with the same dosage.

关 键 词：A型肉毒毒素 脑卒中 上肢痉挛 稀释方法 

分 类 号：R743[医药卫生—神经病学与精神病学]