磷酸钠盐和聚乙二醇电解质口服溶液用于肠道准备的研究  

Bowel preparation with sodium phosphate versus polyethylene glycol： a prospective,randomized, controlled clinical trial

作　　者：杨关根[1] 吴小昌[1] 廖秀军[1] 刘智勇[1] 沈忠[1] 金永军[1] 

机构地区：[1]安徽医科大学杭州临床学院杭州市第三人民医院肛肠科,310009

出　　处：《中华胃肠外科杂志》2009年第2期178-181,共4页Chinese Journal of Gastrointestinal Surgery

摘　　要：目的评价比较口服磷酸钠和聚乙二醇电解质法对肠道清洁的效果及患者的耐受性和安全性。方法将115例住院需行肠道准备的患者按随机数字表随机分组分别应用磷酸钠盐口服液（NaP,试验组）和聚乙二醇（PEG，对照组）进行肠道清洁，通过患者的主观和客观感受、水电解质检测指标和结肠镜肠道清洁效果的评估，对两种肠道准备方法进行比较。结果试验组患者的耐受性评估为（13．5±0．8）分，明显高于对照组的（8．4±0．7）分（t=4．91，P〈0．05）；试验组未饮完率1．8％，与对照组的8．8％比较，差异有统计学意义（P〈0．05）。试验组有效率96．6％，对照组89．5％，两组比较差异有统计学意义（P〈0．05）。试验组与对照组肠道准备前后血清无机磷、血钾和血钙变化百分比分别为64．49±63．83与0．32±12．41、-8．22±6．52与-2．64±12．38和-3．22±5．10与0．83±2．68，两组差异有统计学意义（P〈0．05）。电解质变化在24h内恢复正常，未发现显著性临床效应。结论与聚乙二醇电解质液相比，口服磷酸钠有较好的耐受性和安全性及肠道清洁有效性。Objective To compare the efficacy, tolerance and safety between oral sodium phosphate （NAP） and polyethylene glycol （PEG） on bowel preparation. Methods One hundred and fifteen inpatients were randomly divided into NaP group and PEG group. The questionaire was designed for scoring by patients and doctors regarding to tolerance, taste, side effects and cleaning degree etc. Results Compared with PEG group, NaP presented better tolerance, lower side effects and higher rate of adequate cleaning quality（P〈0.05 ）. NaP could cause electrolytic alterations, such as hyperphosphatemia, hypernatremia, hypocalcemia and hypopotasemia, but these changes were transient and without clinical significance. Conclusion Sodium phosphate is safe and effective for bowel preparation, and is better than polyethylene glycol in tolerance.

关 键 词：肠道准备 磷酸钠 聚乙二醇电解质液 结肠镜检查 

分 类 号：R57[医药卫生—消化系统]