喉鳞状细胞癌中EMS1蛋白的表达  

Expression of EMS1 protein in laryngeal squamous cell carcinoma

作　　者：李继生 李晓杰[2] 谢志斌[2] 李建石 

机构地区：[1]从化市中心医院病理科,广东从化510900 [2]郴州市第一人民医院病理科,湖南郴州423000 [3]郴州市公安局法医科,湖南郴州423000

出　　处：《诊断病理学杂志》2009年第1期18-20,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨EMS1蛋白表达与喉鳞状细胞癌（ISCC）发生、发展及临床病理特征的关系。方法采用免疫组化SP法，对45例ISCC组织（其中40例附癌旁组织）和8例正常喉黏膜组织中EMS1蛋白表达进行检测。结果EMS1蛋白表达定位于细胞的胞质，着色呈黄色至棕黄色；LSCC中阳性表达率82．2％，高于癌旁组织（30％）及正常喉黏膜组织（12．5％）（P〈0．01）；随着组织分级的增高（分化程度的降低），EMS1蛋白阳性表达率明显增高，其差异显著（P〈0．05）；EMS1蛋白的表达与肿瘤的临床分期、淋巴结转移有关，而与性别、年龄、肿瘤大小无关。结论EMS1蛋白的表达可作为LSCC患者疾病进展监控和预后观测的指标，具有临床应用价值。Objective To study the relationship between the expression of EMS1 gene and carcinogenesis, invasion and metastasis. Methods EMS1 protein expression in 45 cases of laryngeal squamous cell carcinoma （ISCC） and 8 cases of normal laryneal mucosa was examined by SP immunohistochemical method. Results EMS1 protein displayed in cytoplasmic localization. The positive rate of EMS1 protein expression was 82.2% in LSCC, and that was 30.0% and 12.5% in their corresponding paracancerous tissues and tunica mucosa laryngis （P 〈 0.001 ）. Overexpression of EMS1 was related to the tumor grade and lymphatic metastasis （ P 〈0.05）. There was no association between EMS1 protein expression and sex, age and tumor size. Conclusion EMS1 protein expression can be a marker in the progression and prognosis of LSCC.

关 键 词：ISCC EMS1蛋白 免疫组化 

分 类 号：R739.65[医药卫生—肿瘤]