多靶点作用药物及其设计  

The multi-target drugs and their design

作　　者：姜凤超[1,2] 

机构地区：[1]华中科技大学同济医学院药学院 [2]天然药物化学与资源评鉴湖北省重点实验室,湖北武汉430030

出　　处：《药学学报》2009年第3期282-287,共6页Acta Pharmaceutica Sinica

摘　　要：疾病起因的多因素性导致单靶点作用药物活性的降低或副作用的增加,利用多靶点作用的药物有可能有利于解决这些问题,本文就多靶点作用药物设计所存在的问题和解决方法进行探讨,提出利用药效团模型法设计多靶点作用药物的理念。The reduce of bioactivity and augment of the side effect of single-target drugs is generated by the multi-factorial properties of the pathogenesis of disease, which could be solved by the multi-target drugs. The problems and its solution of the design of the multi-target drugs were discussed in this paper, at the same time, the design of the multi-target drugs by pharmacophore model method is presented.

关 键 词：多靶点药物 多因素疾病 计算机辅助药物设计 药效团模型 

分 类 号：R916[医药卫生—药学]